The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome.
Simultaneous Delivery Of Receptors And/Or Co-Receptors For Growth Factor Stability And Activity
Elazer R. Edelman - Brookline MA, US Aaron B. Baker - Cambridge MA, US
Assignee:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:
A61K 38/18 A61K 38/17
US Classification:
514 91, 435375, 435377
Abstract:
The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans. Co-delivery of growth factors with syndecans, for example, may protect growth factors from proteolysis, enhance their activity, and target the growth factors to the cell surface to facilitate growth factor signaling. This novel approach to growth factor therapy could be extended to other systems and growth factors enabling the enhancement of multiple signaling pathways to achieve a desired therapeutic outcome.
License Records
Aaron G Baker
Address:
Rumford, RI
License #:
103115 - Active
Issued Date:
Jun 4, 2008
Expiration Date:
Mar 29, 2018
Type:
Appraiser
Aaron G Baker
Address:
Pawtucket, RI 02861
License #:
101631 - Expired
Issued Date:
Nov 17, 2003
Expiration Date:
Mar 29, 2010
Type:
Real Estate Appraiser Trainee
Aaron W Baker
License #:
E052310 - Active
Category:
Emergency medical services
Issued Date:
Jan 1, 2010
Expiration Date:
Dec 31, 2017
Type:
Ventura County EMS Agency
Aaron Baker
License #:
11182 - Expired
Category:
Contractor
Issued Date:
Jun 8, 2005
Name / Title
Company / Classification
Phones & Addresses
Aaron Baker Soc signatory
BAKER APPRAISAL, LLC
76 Freeman St, Norton, MA 02766
Aaron L. Baker Chief, Chief Of Police
City of Pittsburg Urban/Planning Building and Engineering · Police Protection · Air/Water/Waste Management · General Government · Executive Office · Public Finance/Taxation/Monetary Policy · Engineering Services · Regulation/Administrative Utilities
9252524155, 9252524010, 9252524918, 9252524041
Aaron M. Baker
BAKER BROTHERS, LLC
Aaron T. Baker
AARON T. BAKER CO., L.P.A
Aaron M. Baker
ABCS, LLC
Aaron T Baker
SUMMERS & BAKER CO., L.P.A
Aaron Baker Evp Interactive
ATRINSIC, INC Developing Website Ret Children and Women's Apparel · Digital Advertising and Marketing Services Provider · Provider of Digital Advertising and Marketing Services · Telephone Communications · Telephone Communications Management Consulting Services · Business Consulting Services
469 7 Ave 10, New York, NY 10018 469 Fashion Ave, New York, NY 10018 65 Atlantic Ave, Boston, MA 02110 467 Fashion Ave, New York, NY 10018 2127161977, 2122731141
MissouriI grew up on farm in Northeast MO and majored in Ag Econ at Mizzou. I have worked in the official offices of State Senators Cauthorn and Stouffer and worked on... I grew up on farm in Northeast MO and majored in Ag Econ at Mizzou. I have worked in the official offices of State Senators Cauthorn and Stouffer and worked on numerous rural campaigns. My passion is grassroots development and contact management.
Three others on board escaped the flames. One crew member, Sydney Ann Bosmans, 23, of Jupiter, Florida, survived along with passengers Aaron Baker, 35, and Audra Green, 23, who live in Columbus, Ohio.
Date: Feb 13, 2024
Category: U.S.
Source: Google
North Carolina A&T tops Alcorn St. in Celebration Bowl 41-34
Footman threw a 10-yard scoring pass to running back Aaron Baker in the second quarter, caught a 9-yard touchdown from wide receiver Tollette George in the third quarter, and threw an 11-yarder to George to tie it at 27-27 with 12:57 left in the game.
Date: Dec 19, 2015
Category: Sports
Source: Google
ECB's First ABS Purchases Show Caution as Further Steps Debated
If you compare these numbers with the covered-bondpurchases they look limited and there is definitely nobazooka, said Aaron Baker, a London-based analyst at BancoBilbao Vizcaya Argentaria SA. There was a limited supply ofnew deals last week and it is unlikely the ECB will sourcesubstantially
Date: Dec 01, 2014
Category: Business
Source: Google
Three consecutive weeks, and the Samsung Galaxy Note II is the #1 smartphone
Thanks to a fantastic feature set and widespread availability around the world, Samsungs Galaxy Note II continues to dominate PhoneDogs Official Smartphone Rankings," said Aaron Baker, Editor-in-Chief of PhoneDog.
Date: Dec 18, 2012
Category: Sci/Tech
Source: Google
The Samsung Galaxy Note II and Apple iPhone 5 are #1 on the charts this week
While the holiday shopping buzz remains strong around new Android and Windows Phone 8 smartphones, Apples iPhone 5 continues to top the charts, as evident by PhoneDogs Experts Choice Rankings," said Aaron Baker, Editor-in-Chief of PhoneDog.
Date: Nov 26, 2012
Category: Sci/Tech
Source: Google
Samsung smartphones top both sides of the Official Smartphone Rankings
Samsungs Android smartphone portfolio is incredibly compelling, as evident by first place scores on both Official Smartphone Rankings charts," said Aaron Baker, Editor-in-Chief of PhoneDog.
Date: Oct 30, 2012
Category: Sci/Tech
Source: Google
Samsung Galaxy S III and Apple iPhone 5 top the two Official Smartphone ...
Despite its late entry onto PhoneDogs Official Smartphone Rankings, the Apple iPhone 5 is proving to be a fierce competitor to the current high-end Android options," said Aaron Baker, Editor-in-Chief of PhoneDog.
Date: Sep 24, 2012
Category: Sci/Tech
Source: Google
Gov. Andrew Cuomo makes push for privately run casinos
Aaron Baker, deputy director of communications for Monroe County, said County Executive Maggie Brooks is waiting to see Cuomo's op-ed piece before commenting. Rochester spokesman Gary Walker could not be reached for comment Sunday night.