Aaron T Herrmann

US Patent:

20210300918, Sep 30, 2021

Filed:

May 29, 2020

Appl. No.:

16/887889

Inventors:

- Beerse, BE
Wenying Chai - San Diego CA, US
Wendy Eccles - San Diego CA, US
Michael D. Hack - San Diego CA, US
Aaron T. Herrmann - San Diego CA, US
William M. Jones - Jenkintown PA, US
Paul J. Krawczuk - Newtown PA, US
Kevin D. Kreutter - Arlington MA, US
Alec D. Lebsack - Ladera Ranch CA, US
Daniel J. Pippel - San Diego CA, US
Alexander R. Rovira - San Diego CA, US
Ronald L. Wolin - San Diego CA, US

International Classification:

C07D 471/04

Abstract:

The present invention relates to compounds that inhibit NIK and pharmaceutical compositions comprising such compounds and methods of using the same. These compounds and pharmaceutical compositions are envisaged to be useful for preventing or treating diseases such as cancer (such as B-cell malignancies including leukemias, lymphomas and myeloma), inflammatory disorders, autoimmune disorders, immunodermatologic disorders such as palmoplantar pustulosis and hidradenitis suppurativa, and metabolic disorders such as obesity and diabetes.