Aarthi Chandrasekaran from 130 Descanso Dr #406, San Jose, CA 95134, age 43

Us Patents

Methods And Compositions Related To The Modulation Of Intercellular Junctions
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US Patent:

20060067927, Mar 30, 2006
Filed:

Jun 29, 2005
Appl. No.:

11/171490
Inventors:

Aarthi Chandrasekaran - Cambridge MA, US
Shiladitya Sengupta - Waltham MA, US
David Berry - Brookline MA, US
Kristine Holley - Boston MA, US
Ganlin Zhao - Arlington MA, US
Ram Sasisekharan - Bedford MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

A61K 38/47
A61K 31/737
A61K 31/727
US Classification:

424094610, 514054000, 514056000
Abstract:

The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

Methods And Compositions Related To Modulating The Extracellular Stem Cell Environment
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US Patent:

20070020243, Jan 25, 2007
Filed:

Jan 12, 2006
Appl. No.:

11/332766
Inventors:

Shiladitya Sengupta - Waltham MA, US
Ram Sasisekharan - Bedford MA, US
Nishla Keiser - Cambridge MA, US
David Eavarone - North Quincy MA, US
Tanyel Kiziltepe Bilgicer - Cambridge MA, US
Aarthi Chandrasekaran - Cambridge MA, US
David Berry - Brookline MA, US
Kristine Holley - Boston MA, US
Assignee:

Massachusetts Institute of Technology - Cambridge MA
International Classification:

A61K 35/12
C12N 5/08
C12N 5/06
US Classification:

424093700, 435325000, 435366000
Abstract:

This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.

Monitoring Heparin By Microelectronic Devices
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US Patent:

20070212786, Sep 13, 2007
Filed:

Sep 29, 2006
Appl. No.:

11/540695
Inventors:

Scott Manalis - Cambridge MA, US
Tzu Loh - Watertown MA, US
Michel Godin - Somerville MA, US
Nebojsa Milovic - Basel, CH
Jonathan Behr - Cambridge MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Ram Sasisekharan - Cambridge MA, US
International Classification:

G01N 33/86
US Classification:

436069000
Abstract:

In one aspect, the present invention provides a device and method for real-time, direct detection of heparin in buffer and in serum comprising a microfluidic field-effect device as an affinity biosensor. The sensor is based on an electrolyte-insulator-silicon structure, and is manufactured by a standard high-yield silicon microfabrication process. The binding of heparin to the sensor surface induces a change in the insulator-electrolyte surface potential, which is measured as a change in sensor capacitance. To ensure the binding selectivity, protamine and antithrombin III are used as affinity probes.

Hemagglutinin Polypeptides, And Reagents And Methods Relating Thereto
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US Patent:

20080241918, Oct 2, 2008
Filed:

Aug 14, 2007
Appl. No.:

11/893171
Inventors:

Ram Sasisekharan - Cambridge MA, US
Karthik Viswanathan - Cambridge MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Rahul Raman - Cambridge MA, US
Aravind Srinivasan - Cambridge MA, US
S. Raguram - Hillsborough NJ, US
Viswanathan Sasisekharan - Cambridge MA, US
International Classification:

C12N 5/06
C07K 14/00
C12N 15/11
C07K 16/18
C12N 15/00
US Classification:

435325, 530380, 536 235, 4353201, 5303871
Abstract:

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

Hemagglutinin Polypeptides, And Reagents And Methods Relating Thereto
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US Patent:

20090081193, Mar 26, 2009
Filed:

Jan 3, 2008
Appl. No.:

11/969040
Inventors:

Ram Sasisekharan - Bedford MA, US
Karthik Viswanathan - Arlington MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Rahul Raman - Waltham MA, US
Aravind Srinivasan - Cambridge MA, US
S. Raguram - Hillsborough NJ, US
Viswanathan Sasisekharan - Cambridge MA, US
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:

A61K 39/395
C07K 14/435
C07H 21/00
C12N 15/64
C12N 1/21
A61K 31/7088
A61P 31/16
C07K 16/08
C12N 7/01
C40B 40/12
A61K 38/16
US Classification:

4241301, 530324, 536 235, 4353201, 4352523, 5303871, 5303881, 5303891, 4352351, 506 19, 514 12, 514 44
Abstract:

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

Hemagglutinin Polypeptides, And Reagents And Methods Relating Thereto
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US Patent:

20090269342, Oct 29, 2009
Filed:

Jan 2, 2009
Appl. No.:

12/348266
Inventors:

Ram Sasisekharan - Bedford MA, US
Karthik Viswanathan - Arlington MA, US
Aarthi Chandrasekaran - Sunnyvale CA, US
Rahul Raman - Waltham MA, US
Aravind Srinivasan - Cambridge MA, US
S. Raguram - Hillsborough NJ, US
Viswanathan Sasisekharan - Bedford MA, US
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:

A61K 39/395
C07K 14/00
C12N 15/11
C12N 15/00
C12N 5/06
C07K 16/18
C12N 7/00
A61K 38/02
C40B 40/10
C40B 30/04
G01N 33/566
US Classification:

4241351, 530396, 536 231, 4353201, 435325, 435350, 435364, 5303879, 4352351, 514 2, 4241391, 506 18, 506 9, 436501, 4241331
Abstract:

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.

Decoy Influenza Therapies
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US Patent:

20100004195, Jan 7, 2010
Filed:

Jan 2, 2009
Appl. No.:

12/348265
Inventors:

Ram Sasisekharan - Bedford MA, US
Karthik Viswanathan - Arlington MA, US
Aarthi Chandrasekaran - Sunnyvale CA, US
Rahul Raman - Waltham MA, US
Aravind Srinivasan - Cambridge MA, US
S. Raguram - Hillsborough NJ, US
Viswanathan Sasisekharan - Bedford MA, US
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:

A61K 31/702
C12Q 1/70
C07H 1/00
US Classification:

514 54, 435 5, 5361231
Abstract:

The present invention provides umbrella-topology glycan decoys. The present invention provides systems and methods treating influenza infection utilizing inventive umbrella-topology glycan decoys. The present invention provides methods for identifying novel umbrella-topology glycan decoys.

Hemagglutinin Polypeptides, And Reagents And Methods Relating Thereto
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US Patent:

20100061990, Mar 11, 2010
Filed:

Aug 14, 2007
Appl. No.:

12/301126
Inventors:

Ram Sasisekharan - Bedford MA, US
Karthik Viswanathan - Arlington MA, US
Aarthi Chandrasekaran - Cambridge MA, US
Rahul Raman - Waltham MA, US
Aravind Srinivasan - Cambridge MA, US
S. Raguram - Hillsborough NJ, US
Viswanathan Sasisekharan - Bedford MA, US
Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - Cambridge MA
International Classification:

A61K 39/395
G01N 33/53
C40B 40/12
US Classification:

4241391, 436501, 435 71, 506 19
Abstract:

The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.