Adam W Conner

US Patent:

7393826, Jul 1, 2008

Filed:

Oct 26, 2005

Appl. No.:

11/260861

Inventors:

Marc Bellotti - Pleasanton CA, US
Hassibullah Akeefe - San Ramon CA, US
Adam Paul Conner - Salida CA, US
Timothy Jon Perlman - Pleasanton CA, US

Assignee:

Lipid Sciences, Inc. - Pleasanton CA

International Classification:

A01N 37/18

US Classification:

514 2

Abstract:

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

US Patent:

7375191, May 20, 2008

Filed:

Mar 8, 2004

Appl. No.:

10/796691

Inventors:

Marc Bellotti - Pleasanton CA, US
Hassibullah Akeefe - Antioch CA, US
Adam Paul Conner - Livermore CA, US
Timothy Jon Perlman - Pleasanton CA, US

Assignee:

Lipid Science, Inc. - Pleasanton CA

International Classification:

C07K 1/00

US Classification:

530359

Abstract:

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

US Patent:

7361739, Apr 22, 2008

Filed:

Nov 23, 2004

Appl. No.:

10/996570

Inventors:

Marc Bellotti - Pleasanton CA, US
Hassibullah Akeefe - Antioch CA, US
Adam Paul Conner - Livermore CA, US
Timothy Jon Perlman - Pleasanton CA, US

Assignee:

Lipid Sciences, Inc. - Pleasanton CA

International Classification:

C07K 1/00

US Classification:

530359

Abstract:

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

US Patent:

20080214438, Sep 4, 2008

Filed:

Mar 5, 2008

Appl. No.:

12/042924

Inventors:

Marc Bellotti - Pleasanton CA, US
H. Bryan Brewer - Potomac MD, US
Hassibullah Akeefe - Antioch CA, US
Adam Paul Conner - Livermore CA, US
Timothy Jon Perlman - Pleasanton CA, US

International Classification:

A61K 38/02

US Classification:

514 2

Abstract:

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

US Patent:

20140050763, Feb 20, 2014

Filed:

Oct 30, 2013

Appl. No.:

14/067081

Inventors:

JO-ANN B. MALTAIS - SAN RAMON CA, US
MARC BELLOTTI - COTO DE CAZA CA, US
ADAM PAUL CONNER - WARSAW IN, US
HASSIBULLAH AKEEFE - SAN RAMON CA, US
MOIZ KITABWALLA - LIVERMORE CA, US

Assignee:

ELI LILLY & COMPANY - INDIANAPOLIS IN

International Classification:

A61K 39/29
A61K 39/12

US Classification:

4242181, 530350, 4242271

Abstract:

The present invention relates to a method for reducing the occurrence and severity of infectious diseases, especially infectious diseases in which lipid-containing infectious viral organisms are found in biological fluids, such as blood. The present invention employs solvents useful for extracting lipids from the lipid-containing infectious viral organism thereby creating modified viral particles with reduced infectivity and enhanced antigenicity. The present invention provides vaccine compositions, comprising these modified viral particles with reduced infectivity and enhanced antigenicity, optionally combined with a pharmaceutically acceptable carrier or an immunostimulant. The vaccine composition is administered to a patient to provide protection against the lipid-containing infectious viral organism. The vaccine compositions of the present invention include combination vaccines of modified viral particles obtained from one or more strains of a virus and/or one or more types of virus.