Adam K Gilbert

US Patent:

7947712, May 24, 2011

Filed:

Aug 23, 2007

Appl. No.:

11/895222

Inventors:

Matthew G. Bursavich - Tuckahoe NY, US
Sabrina Lombardi - Wilton CT, US
Adam M. Gilbert - Congers NY, US
Leif Mark Laakso - Chester NY, US
Gulnaz Khafizova - West Nyack NY, US
David Brian How - Nyack NY, US
Joshua James Sabatini - White Plains NY, US
Jeremy Clemens - New City NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

C07D 215/04
A61K 31/04

US Classification:

514312, 546159, 546167

Abstract:

The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.

US Patent:

8633215, Jan 21, 2014

Filed:

Jun 18, 2009

Appl. No.:

12/487309

Inventors:

Roberto Pellicciari - Perugia, IT
Flavio Moroni - Florence, IT
Eric Christian Hansen - Ridgewood NJ, US
Adam Matthew Gilbert - Congers NY, US
Peter John Larkin - Trumbull CT, US

International Classification:

C07D 491/048
A61K 31/4355
A61K 31/4365

US Classification:

514292, 546 81

Abstract:

The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

US Patent:

20080125469, May 29, 2008

Filed:

Jun 7, 2007

Appl. No.:

11/810911

Inventors:

Matthew G. Bursavich - Tuckahoe NY, US
Sabrina Lombardi - New Haven CT, US
Adam M. Gilbert - Congers NY, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/433
C07D 285/14
A61P 35/00
A61P 19/02

US Classification:

514363, 548126

Abstract:

The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of a Thiadiazole Compound to a mammal in need thereof.

US Patent:

57505748, May 12, 1998

Filed:

Jul 7, 1997

Appl. No.:

8/889163

Inventors:

Adam M. Gilbert - Valley Cottage NY

Assignee:

American Home Products Corporation - Madison NJ

International Classification:

A61K 31135
A61K 31165
C07C22520
C07C23582

US Classification:

514604

Abstract:

A compound of the general formula (I) ##STR1## wherein R. sub. 1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R. sub. 2 and R. sub. 3 are, independently, hydrogen or an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is a substituted phenyl group of the following formula: ##STR2## wherein R. sub. 4 is F, perfluoroalkyl group of 1 to 10 carbon atoms or perfluoroalkoxy of 1 to 10 carbon atoms; or a pharmaceutically acceptable salt thereof relax smooth muscles.

US Patent:

20140107117, Apr 17, 2014

Filed:

Dec 13, 2013

Appl. No.:

14/106228

Inventors:

Roberto Pellicciari - Corciano, IT
Flavio Moroni - Firenze, IT
Eric Christian Hansen - Ridgewood NJ, US
Adam Matthew Gilbert - Guilford CT, US
Peter John Larkin - Trumbull CT, US

International Classification:

C07D 495/04
C07D 491/048

US Classification:

5142338, 514291

Abstract:

The present invention relates to substituted thienyl- and furanyl-isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.