Adam Lopez Hernandez

US Patent:

20150119740, Apr 30, 2015

Filed:

Jul 2, 2012

Appl. No.:

14/129556

Inventors:

Adam Breaux Hernandez - Baltimore MD, US
Jason Kirkness - Baltimore MD, US
Hartmut Schneider - Lutherville MD, US
Mikhael Polotsky - Baltimore MD, US
Alan Schwartz - Baltimore MD, US
Philip Smith - Baltimore MD, US
Walter Hernandez - Potomac MD, US

Assignee:

THE JOHNS HOPKINS UNIVERSITY - Baltimore MD

International Classification:

A61B 5/08
A61B 5/0488
A61B 5/00
A61B 5/0476

US Classification:

600529, 600301

Abstract:

An embodiment in accordance with the present invention provides a device for whole-body plethysmography (WBP) of a mouse for the continuous characterization of sleep and breathing. The inherent limitations of standard WBP are addressed to enable the continuous recording of validated measures of tidal volume, tidal airflow, and respiratory effort surrogate in an unrestrained, unanesthetized mouse. The addition of standard EEG and EMG recording technology allows for respiratory patterns to be fully characterized during sleep and wakefulness. The present invention also allows for the demonstration of the development of dynamic upper airway obstruction [inspiratory flow limitation (IFL)] during sleep in a susceptible, obese murine strain.