Adam B Simon

Address:

76 Bishop St #2, New Haven, CT 06511

VIN:

JF1GD75617G502497

Make:

SUBARU

Model:

IMPREZA

Year:

2007

US Patent:

7196163, Mar 27, 2007

Filed:

Apr 30, 2003

Appl. No.:

10/427208

Inventors:

Daria Jean Hazuda - Doylestown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Min Xu - Ambler PA, US
Xiao-Ping Shi - Warrington PA, US
Adam J. Simon - Langhorne PA, US
Guoxin Wu - Merion Station PA, US
Yueming Li - New York NY, US
Bruce Register - Berwyn PA, US

Assignee:

Merk & Co., Inc. - Rahway NJ

International Classification:

A61K 38/07
A61K 38/16

US Classification:

530330, 530350, 514 2, 514 18, 435 71, 424 9463

Abstract:

Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of the β-secretase cleavage site. Many of the modified β-secretase substrates are more efficient substrates for β-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by β-secretase. Recombinant polynucleotide molecules encoding the modified β-secretase substrates are provided. Antibodies that recognize cleavage products of the modified β-secretase substrates are provided. Stable cell lines expressing the modified β-secretase substrates are provided.

US Patent:

20040091853, May 13, 2004

Filed:

Aug 25, 2003

Appl. No.:

10/469199

Inventors:

Daria Hazuda - Doylestown PA, US
Janet Lineberger - Ambler PA, US
Michael Miller - Chalfont PA, US
Adam Simon - Langhorne PA, US

International Classification:

C12Q001/70
C07H021/04
C12N007/00
C07K014/16
C07H021/02

US Classification:

435/005000, 435/069300, 435/235100, 435/320100, 435/325000, 530/395000, 536/023720

Abstract:

The present invention features a chimeric protein containing a -lactamase region and either a Vpr region or a Vpx region. The chimeric protein can be packaged into a viral reporter particle, introduced into a cell recognized by the viral particle and provide intracellular -lactamase activity.

US Patent:

20070219354, Sep 20, 2007

Filed:

Mar 7, 2007

Appl. No.:

11/714985

Inventors:

Daria Hazuda - Doylestown PA, US
Elizabeth Chen Dodson - Souderton PA, US
Min Xu - Ambler PA, US
Xiao-Ping Shi - Warrington PA, US
Adam Simon - Langhorne PA, US
Guoxin Wu - Merion Station PA, US
Yueming Li - New york NY, US
Bruce Register - Berwyn PA, US

International Classification:

C07K 16/00
C07K 14/00

US Classification:

530387900, 530395000

Abstract:

Provided are methods of identifying inhibitors of β-secretase that employ modified β-secretase substrates. The modified β-secretase substrates have β-secretase cleavage sites that are altered from wild type. The amino acid sequences of the altered β-secretase cleavage sites contain different amino acids in at least one of the positions P2-P1-P1′-P2′ of the β-secretase cleavage site. Many of the modified β-secretase substrates are more efficient substrates for β-secretase than are corresponding substrates having wild-type sequences, that is, these modified substrates are more susceptible to enzymatic breakdown by β-secretase. Recombinant polynucleotide molecules encoding the modified β-secretase substrates are provided. Antibodies that recognize cleavage products of the modified β-secretase substrates are provided. Stable cell lines expressing the modified β-secretase substrates are provided. Transgenic animals expressing the modified β-secretase substrates are provided.

US Patent:

20070292895, Dec 20, 2007

Filed:

May 14, 2007

Appl. No.:

11/803207

Inventors:

Xiao-Ping Shi - Warrington PA, US
Guoxin Wu - Merion Station PA, US
Jason Kahana - Schwenksville PA, US
Adam Simon - Yardley PA, US

International Classification:

G01N 33/573

US Classification:

435007400

Abstract:

Methods and assays for detecting β-secretase (BACE-1) activity in body fluids or tissue extracts from individuals, particularly individuals who have Alzheimer's disease, are disclosed. A truncated form of BACE-1 was isolated that can be used as a biomarker for Alzheimer's disease.

US Patent:

20170032098, Feb 2, 2017

Filed:

Apr 7, 2015

Appl. No.:

15/302535

Inventors:

Parham GHORBANIAN - Wayne PA, US
Hashem ASHRAFIUON - Wayne PA, US
Adam J. SIMON - Yardley PA, US

International Classification:

G06F 19/00
A61B 5/0476
A61B 5/00

Abstract:

A system and method for modeling bio-signals in the form of non-linear stochastic oscillators by extracting time series data from a subject into a series of summary fit parameters and comparing the unknown fit parameters to a set of normative fit parameters to determine whether the subject should be included in a group or not. The method includes data collection, feature extraction and then comparison of fit parameters from a non-linear stochastic oscillator model to a normative standard to make the in or out determination for a particular group. The system includes a processor programmed to perform the steps of the method.