Adrian Denise Smith

US Patent:

20160280695, Sep 29, 2016

Filed:

Nov 4, 2015

Appl. No.:

14/932787

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Reseda CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 413/12

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

US Patent:

20150252011, Sep 10, 2015

Filed:

Apr 21, 2015

Appl. No.:

14/691715

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Reseda CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

International Classification:

C07D 265/12
C07D 413/04
C07D 413/10
C07D 413/14
C07D 417/12
C07D 417/14
C07D 413/12
C07D 471/04

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

US Patent:

20140275058, Sep 18, 2014

Filed:

Mar 6, 2014

Appl. No.:

14/199844

Inventors:

- Thousand Oaks CA, US
Jonathan D. LOW - Tarzana CA, US
Jennifer R. ALLEN - Newbury Park CA, US
Albert AMEGADZIE - Moorpark CA, US
James BROWN - Moorpark CA, US
Michael J. FROHN - Thousand Oaks CA, US
Angel GUZMAN-PEREZ - Belmont MA, US
Paul E. HARRINGTON - Camarillo CA, US
Patricia LOPEZ - Woodland Hills CA, US
Vu Van MA - Oak Park CA, US
Nobuko NISHIMURA - West Hills CA, US
Wenyuan QIAN - Newbury Park CA, US
Shannon RUMFELT - Camarillo CA, US
Robert M. RZASA - Ventura CA, US
Kelvin SHAM - Thousand Oaks CA, US
Adrian L. SMITH - Simi Valley CA, US
Ryan WHITE - Somerville MA, US
Qiufen XUE - Newbury Park CA, US

International Classification:

C07D 471/04
C07D 265/12
C07D 417/12
C07D 417/14
C07D 413/12
C07D 413/14

US Classification:

5142305, 544 90

Abstract:

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:wherein variables A, A, A, A, each of R, R, R, R, Rand Rof Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.