Adrienne B Hoeglund

US Patent:

20120100592, Apr 26, 2012

Filed:

Oct 26, 2010

Appl. No.:

12/912604

Inventors:

Daniel Lee Baker - Memphis TN, US
Adrienne Hoeglund - Collierville TN, US

International Classification:

C12N 9/99
C07D 471/04

US Classification:

435184, 544117, 544279

Abstract:

Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.