James A. Shayman - Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Miki Hiraoka - Ann Arbor MI, US
Assignee:
The Regents of The University of Michigan - Ann Arbor MI
International Classification:
C12Q 1/42
US Classification:
435 21, 435198, 424 946
Abstract:
The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
Methods And Compositions For Using Aleveolar Macrophage Phospholipase A2
James A. Shayman - Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Miki Hiraoka - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
C12Q 1/42
US Classification:
435 21, 435198, 424 946
Abstract:
The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
Lysosomal Phospholipase A2 (Lpla2) Activity As A Diagnostic And Therapeutic Target For Identifying And Treating Systemic Lupus Erythematosis
James A. Shayman - Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Robert Kelly - Trenton MI, US Jessica Kollmeyer - Ypsilanti MI, US Ye Lu - Ann Arbor MI, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 38/46
US Classification:
424 946, 424 94, 435375, 435 19
Abstract:
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus.
Lysosomal Phospholipase A2 (Lpla2) Activity As A Diagnostic And Therapeutic Target For Identifying And Treating Systemic Lupus Erythematosis
James A. Shayman - Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Robert Kelly - Trenton MI, US Jessica Kollmeyer - Ypsilanti MI, US Ye Lu - Ann Arbor MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 38/46 A61P 29/00
US Classification:
424 946
Abstract:
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus.
Glucosylceramide Synthase Inhibitors And Therapeutic Methods Using The Same
The Regents of The University of Michigan - Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Liming Shu - Ann Arbor MI, US Michael William Wilson - Ann Arbor MI, US Richard F. Keep - Ann Arbor MI, US James A. Shayman - Ann Arbor MI, US
Assignee:
The Regents of The University of Michigan - Ann Arbor MI
424 941, 548526, 514422, 548569, 514428, 548568, 514 44 R
Abstract:
Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
Glucosylceramide Synthase Inhibitors And Therapeutic Methods Using The Same
- Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Liming Shu - Ann Arbor MI, US Michael William Wilson - Ann Arbor MI, US Richard F. Keep - Ann Arbor MI, US Duxin Sun - Ann Arbor MI, US James A. Shayman - Ann Arbor MI, US
Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.
Lysosomal Phospholipase A2 (Lpla2) Activity As A Diagnostic And Therapeutic Target For Identifying And Treating Systemic Lupus Erythematosus
- Ann Arbor MI, US Akira Abe - Ann Arbor MI, US Robert Kelly - Trenton MI, US Jessica Kollmeyer - Ypsilanti MI, US Ye Lu - Ann Arbor MI, US
International Classification:
A61K 38/45 G01N 33/68
Abstract:
The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagnosis and treatment of autoimmune disorders such as systemic lupus erythematosus and drug-induced systemic lupus erythematosus.