Alan Russell Cook

US Patent:

6532463, Mar 11, 2003

Filed:

Dec 1, 1998

Appl. No.:

09/203686

Inventors:

James Earl Robbins - Gainesville FL
Alan Russell Cook - Gainesville FL
Michael Wayne Lucas - Gainesville FL

Assignee:

University of Florida - Gainesville FL

International Classification:

G06F 1730

US Classification:

707 9, 707 10, 713182

Abstract:

A method of providing Web access to data using dynamic generation of Web pages by a mainframe computer connected to a Web server. The mainframe computer has legacy programs, legacy data, and legacy subroutines on it (Legacy means existing information systems which may not be specifically adapted to Web access). A Web control program on the mainframe marries file definition objects and page definition objects to generate Web pages and allow a Web user to access legacy data stored in databases on the mainframe. A state key is generated by the mainframe upon a user inputting identification data and the state key is then incorporated into the Web page generated by the Web control program. By receiving the state key back from the user, the Web control program determines the extent of access allowed to a particular user without the user having to reenter identification data. The Web control program allows one to manage and change the appearance of Web pages.

US Patent:

40716805, Jan 31, 1978

Filed:

Dec 20, 1976

Appl. No.:

5/752510

Inventors:

Alan Frederick Cook - Cedar Grove NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07H 1906

US Classification:

536 23

Abstract:

Novel 5'-deoxy-5-fluoropyrimidine nucleosides are potent anti-tumor agents. Preferred compounds are 5'-deoxy-5-fluorocytidine and 5'-deoxy-5-fluorouridine.

US Patent:

61722081, Jan 9, 2001

Filed:

Jul 6, 1992

Appl. No.:

7/908376

Inventors:

Alan Frederick Cook - Cedar Grove NJ

Assignee:

Genzyme Corporation - Framingham MA

International Classification:

C07H 2104

US Classification:

536 231

Abstract:

An oligonucleotide wherein at least one nucleotide unit of the oligonucleotide is conjugated with a moiety selected from the group consisting of: (a) amino acids; (b) dipeptide mimics; (c) sugars; (d) sugar phosphates; (e) neurotransmitters; (f) poly-hydroxypropylmethacrylamide; (g) dextrans; (h) polymaleic anhydride; (i) cyclodextrins; (j) starches; and (k) polyethyleneimine. The oligonucleotides may be employed for binding to an RNA, and DNA, a protein, or a peptide to inhibit or prevent gene transcription or gene expression, to inhibit or stimulate the activities of target molecules, or the oligonucleotides may be employed as diagnostic probes for determining the presence of specific DNA or RNA sequences or proteins.

US Patent:

41489934, Apr 10, 1979

Filed:

Feb 10, 1978

Appl. No.:

5/876768

Inventors:

Alan F. Cook - Cedar Grove NJ
Ronald J. Quinn - Cromer, AU

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07H 1700
A61K 3170

US Classification:

536 24

Abstract:

A process to produce 1-methyl isoquanosine, a compound of the formula ##STR1## is disclosed. Also disclosed is a novel intermediate in said process. The 1-methyl isoguanosine has been found to have pharmacological activity, e. g. anti-inflammatory activity and muscle relaxant activity.

US Patent:

59199652, Jul 6, 1999

Filed:

Jan 18, 1995

Appl. No.:

8/374040

Inventors:

Robert Gerard Gentles - Hackcnsack NJ
Alan F. Cook - Cedar Grove NJ
Morris Jonathan Rudolph - Boonton NJ
Reza Fathi - Newark NJ

Assignee:

Genzyme Corporation - Cambridge MA

International Classification:

C07F 906
C07F 9141
C07D23360
C07D24104

US Classification:

558 70

Abstract:

A phosphorus ester oligomer having the structure: ##STR1## wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, alkyl- or aryl-substituted amino and aminoalkyl; B. sub. 1 and B. sub. 2 can be the same or different and each is independently selected from hydrogen, lower alkyl, a labelling group, a protecting group, a phosphoramidate or a phosphomonoester; R. sub. 1 can be the same or different in each monomeric unit, and in at least one of the non-nucleotide monomeric units, R. sub. 1 is independently selected from the group consisting of a condensation product of (i) a non-vicinal diol attached to a hydrogen bond donor functionality; (ii) a hydrogen bond acceptor selected from an ether, a purine or pyrimidine substituted 1,2-diol or a disubstituted heterocycle; (iii) a non-vicinal diol attached to a hydrophobic functionality or a vicinal diol attached to an aliphatic or alicyclic hydrophobic functionality (iv) a diol attached to a ring substituted anionic functionality and (v) a cationic moiety attached to a non-vicinal or alicyclic diol, any of which can further include a detectable label, and n is at least one. Preferred R. sub. 1 moieties include condensation products of heterocyclic diols, alicyclic diols, and polycyclic diols.

US Patent:

60178957, Jan 25, 2000

Filed:

Feb 10, 1992

Appl. No.:

7/833146

Inventors:

Alan Frederick Cook - Cedar Grove NJ

Assignee:

Genzyme Corporation - Framingham MA

International Classification:

A61K 31715
A61K 3804
C07H 2100
C07H 2104

US Classification:

514 44

Abstract:

An oligonucleotide wherein at least one nucleotide unit includes a phosphonate moiety having the following structural formula: ##STR1## , wherein X is a zwitterionic moiety. Such oligonucleotides have improved cellular uptake capabilities and improved resistance against nuclease activity.