Alan O Fiona Cowan

US Patent:

6353004, Mar 5, 2002

Filed:

Oct 9, 1998

Appl. No.:

09/168724

Inventors:

John J. Farrar - Chester Springs PA
Alan Cowan - Ambler PA

Assignee:

Adolor Coporation - Malvern PA

International Classification:

A61K 31445

US Classification:

514327, 514317, 514318, 514326, 514406

Abstract:

Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R , R , R , R , Ar and Ar are as defined in the specification in a pharmaceutically acceptable carrier.

US Patent:

6900189, May 31, 2005

Filed:

Sep 25, 2001

Appl. No.:

09/964178

Inventors:

Robert Raffa - Norristown PA, US
Alan Cowan - Ambler PA, US
Ronald Tallarida - Mantua NJ, US

International Classification:

A61K031/192
A61K031/7008

US Classification:

514 62, 514570

Abstract:

This invention relates to a composition comprising a glucosamine material and an analgesic compound such as a nonsteroidal anti-inflammatory drug (NSAID) and/or an opioid analgesic and its use for treatment of pain in pharmaceutical or veterinary applications. When the components of the compositions are administered within certain ratios, the analgesic efficacy of the composition is super-additive (synergistic) relative to the analgesic efficacy of the analgesic compound alone.

US Patent:

7662803, Feb 16, 2010

Filed:

Mar 31, 2007

Appl. No.:

11/731600

Inventors:

Alan Cowan - Ambler PA, US
Robert B. Raffa - Norristown PA, US
Ronald J. Tallarida - Mantua NJ, US

Assignee:

Gluconova, LLC - Wilmington DE

International Classification:

A01N 43/04
A01N 43/08
C07H 5/04
C07H 5/06
C07H 17/04

US Classification:

514 62, 536 552, 536 172

Abstract:

A method of treating a warm-blood vertebrate. The vertebrate may be a human being or a lower animal. The treatment method involves administering to the vertebrate in need of such treatment a pharmaceutically effective amount of a complex of halide-free glucosamine and a therapeutic drug having a pKof less than 7. Preferably, the complex is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers, povidone homopolymers and copolymers, polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant polymer-coated complex will be stable upon exposure to ambient temperature and/or the atmosphere. Suitable acidic therapeutic drugs may be found in one or more of the following classes of therapeutic drugs: α- and β-Adrenergic Agonists; Narcotic and Non-Narcotic Analgesics; Anorexics; Antiallergics; Antianginals; Antiarrhythmics; Antiasthmatics; Antibiotics; Anti-coagulants; Anticonvulsants; Antidepressants; Antidiabetics; Antihistaminics; Anti-hypertensives; Nonsteroidal Anti-Inflammatories; Antimigraines; Antineoplastics; Antiparkinsonians; Antipsychotics; Antipyretics; Antispasmodics; Antithrombotics; Anti-ulceratives; Anxiolytics; Decongestants; Diuretics; Hepatoprotectants; Sedatives; and Vasodilators.

US Patent:

20070248677, Oct 25, 2007

Filed:

Sep 9, 2005

Appl. No.:

11/223295

Inventors:

Alan Cowan - Ambler PA, US
Robert Raffa - Norristown PA, US
Ronald Tallarida - Mantua NJ, US

International Classification:

A61K 31/7008
A61K 9/14

US Classification:

424487000, 514062000

Abstract:

A method of treating a warm-blood vertebrate. The verebrate may be a human being or a lower animal. The treatment method involves administering to the vertebrate in need of such treatment a pharmaceutically effective amount of a salt of a halide-free glucosamine base and a therapeutic drug containing at least one acid functionality, e.g., a carbonyl moiety, a carboxyl moiety, a sulfoxide moiety, etc. Preferably, the salt is stabilized by coating it with at least one pharmaceutically acceptable polymer comprising a water-soluble, water-immiscible and/or water-swellable homopolymer and/or copolymer. Suitable polymers include carboxypolymethylene homopolymers and copolymers; polyethylene glycol homopolymers and copolymers, povidone homopolymers and copolymers; polyacrylic acid homopolymers and copolymers; polyacrylamide homopolymers and copolymers; polysaccharides; and mixtures of two or more of the foregoing polymers. The resultant coated halide-free glucosamine-therapeutic drug salt composition will be stable upon exposure to ambient temperature and/or the atmosphere. Suitable therapeutic drugs containing at least one acid functionality may be found in one or more of the following classes of therapeutic drugs. α- and β-Adrenergic Agonists; Narcotic and Non-Narcotic Analgesics; Anorexics; Antiallergics; Antianginals; Antiarrhythmics; Antiasthmatics; Antibiotics; Anti-coagulants; Anticonvulsants; Antidepressants; Antidiabetics; Antihistaminics; Anti-hypertensives; Nonsteroidal Anti-Inflammatories; Antimigraines; Antineoplastics; Antiparkinsonians; Antipsychotics; Antipyretics; Antispasmodics; Antithrombotics; Anti-ulceratives; Anxiolytics; Decongestants; Diuretics; Hepatoprotectants; Sedatives; and Vasodilators.

US Patent:

60488603, Apr 11, 2000

Filed:

Oct 4, 1999

Appl. No.:

9/411111

Inventors:

John J. Farrar - Chester Springs PA
An-Chih Chang - Bensalem PA
Virendra Kumar - Paoli PA
Wei Yuan Zhang - Collegeville PA
Alan Cowan - Ambler PA

Assignee:

Adolor Corporation - Malvern PA

International Classification:

A61K 31495
A61K 3150
A61K 31505
A61K 3147
A61K 31445

US Classification:

514252

Abstract:

Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

US Patent:

57600236, Jun 2, 1998

Filed:

Jul 14, 1997

Appl. No.:

8/892599

Inventors:

John J. Farrar - Chester Springs PA
An-Chih Chang - Bensalem PA
Virendra Kumar - Paoli PA
Wei Yuan Zhang - Collegeville PA
Alan Cowan - Ambler PA

Assignee:

Adolor Corporation - Malvern PA

International Classification:

A61K 3116
A61K 3140
A61K 31655

US Classification:

514150

Abstract:

Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

US Patent:

58695214, Feb 9, 1999

Filed:

Apr 22, 1998

Appl. No.:

/064695

Inventors:

John J. Farrar - Chester Springs PA
An-Chih Chang - Bensalem PA
Virendra Kumar - Paoli PA
Wei Yuan Zhang - Collegeville PA
Alan Cowan - Ambler PA

Assignee:

Adolor Corporation - Malvern PA

International Classification:

A61K 3140

US Classification:

514422

Abstract:

Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.

US Patent:

61567698, Dec 5, 2000

Filed:

Jan 20, 2000

Appl. No.:

9/488420

Inventors:

John J. Farrar - Chester Springs PA
An-Chih Chang - Bensalem PA
Virendra Kumar - Paoli PA
Wei Yuan Zhang - Collegeville PA
Alan Cowan - Ambler PA

Assignee:

Apolor Corp. - Malvern PA

International Classification:

A61K 31445

US Classification:

514320

Abstract:

Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.