John R. Hackett - Libertyville IL, US Julie Yamaguchi - Chicago IL, US Alan M. Golden - Wilmette IL, US Catherine A. Brennan - Libertyville IL, US Robert K. Hickman - Mundelein IL, US Sushil G. Devare - Northbrook IL, US
Assignee:
Abbott Laboratories, Inc. - Abbott Park IL
International Classification:
C07K 14/16
US Classification:
530350, 530300
Abstract:
Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.
A casino craps table layout is provided with unique wagering opportunities. There are specific wagering areas for placing a wager on at least one of two new wagering opportunities. These new wagering opportunities are selected from the group consisting of a) a wager that the next roll of the dice will be a hard 4, 6, 8 or 10 and b) a wager that the next roll of the dice will be a pair of numbers. Another new wagering opportunity is a placed wager for any specific number (e. g. , 4, 5, 6, 8, 9, and 10).
John R. Hackett - Gurnee IL Jane A. Hoff - Naperville IL David H. Ostrow - Lake Zurich IL Alan M. Golden - Wilmette IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
G01N 33569 G01N 33577
US Classification:
435 5
Abstract:
The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.
Rapid Assay For Simultaneous Detection And Differentiation Of Antibodies To Hiv Groups
Anadruzela S. Vallari - Libertyville IL John R. Hackett - Libertyville IL Robert K. Hickman - Mundelein IL Vincent A. Varitek - Wildwood IL Elizabeth C. Necklaws - Grayslake IL Alan M. Golden - Wilmette IL Catherine A. Brennan - Libertyville IL Sushil G. Devare - Northbrook IL
Assignee:
Abbott Laboratories - Abbott Park IL
International Classification:
C12Q 170
US Classification:
435 5
Abstract:
A method of performing a rapid assay for the simultaneous detection and differentiation of the analytes HIV-1 group M. HIV-1 group O and HIV-2 utilizing a sequence specific polypeptide of each analyte as capture reagents. An analytical. device also is provided for performing the method which includes these capture reagents. Also provided is a test kit which includes the analytical device which further can include a positive and negative control.