Albert C Mossa

US Patent:

7238517, Jul 3, 2007

Filed:

Oct 22, 2003

Appl. No.:

10/691186

Inventors:

John Girdner Atwood - West Redding CT, US
Albert Carmelo Mossa - Trumbull CT, US
Lisa May Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy M. Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert P. Ragusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Raphael CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12M 1/38

US Classification:

4352861, 4353031, 435809, 422943, 700269, 700274, 700300

Abstract:

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.

US Patent:

7504241, Mar 17, 2009

Filed:

May 12, 2006

Appl. No.:

11/433872

Inventors:

John Girdner Atwood - West Redding CT, US
Albert Carmelo Mossa - Trumbull CT, US
Lisa May Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy M. Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert P. Ragusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Rafael CA, US

Assignee:

Applied Biosystems, LLC - Carlsbad CA

International Classification:

C12P 19/34
C12M 1/38

US Classification:

435 912, 4352872, 4353031, 435809

Abstract:

A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.

US Patent:

20020072112, Jun 13, 2002

Filed:

Jan 11, 2000

Appl. No.:

09/481552

Inventors:

JOHN GIRDNER ATWOOD - WEST REDDING CT, US
ALBERT CARMELO MOSSA - TRUMBULL CT, US
LISA MAY GOVEN - BRIDGEPORT CT, US
FENTON WILLIAMS - BROOKFIELD CT, US
TIMOTHY M. WOUDENBERG - BETHEL CT, US
ROBERT P. RAGUSA - NEWTON CT, US
RICHARD LEATH - BERKLEY CA, US
CLIVE MILES - SAN RAFAEL CA, US

International Classification:

C12M001/36

US Classification:

435/303100, 435/305300, 435/287200

Abstract:

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.

US Patent:

20050084957, Apr 21, 2005

Filed:

Aug 30, 2004

Appl. No.:

10/929961

Inventors:

John Atwood - West Redding CT, US
Susan Stone - Charlotte VT, US
Judith Atwood - Redding CT, US
Albert Mossa - Trumbull CT, US
Lisa Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert Ragusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Raphael CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12M001/24

US Classification:

435304100

Abstract:

A sample tube including a cylindrical part and a conical part is described. The cylindrical part can include, a first wall portion having a first wall portion thickness, a second wall portion having a second wall portion thickness, and a shoulder including a planar first surface and a conically beveled second surface disposed between the first wall portion and the second wall portion. The first wall portion can be disposed closer to the planar first surface than the conically beveled second surface. The conical part can be shaped as a frustrum of a cone having a conical part wall thickness. The frustrum can include a wider-end and a narrower-end. The wider-end of the frustrum can be in contact with the second wall portion of the cylindrical part. At least one of the first wall portion thickness and the second wall portion thickness can be greater than the conical part wall thickness.

US Patent:

20060269641, Nov 30, 2006

Filed:

May 12, 2006

Appl. No.:

11/433892

Inventors:

John Atwood - West Redding CT, US
Albert Mossa - Trumbull CT, US
Lisa Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert Ragusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Rafael CA, US

Assignee:

Applera Corporation - Foste City CA

International Classification:

B01L 9/00

US Classification:

425286000, 422099000

Abstract:

A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.

US Patent:

20080299651, Dec 4, 2008

Filed:

Dec 4, 2007

Appl. No.:

11/999179

Inventors:

John Girdner Atwood - West Redding CT, US
Albert Carmelo Mossa - Trumbull CT, US
Lisa May Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy M. Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert P. Ragusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Rafael CA, US

Assignee:

Applera Corporation - Foster City CA

International Classification:

C12M 1/00

US Classification:

4353031

Abstract:

A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.

US Patent:

20090155765, Jun 18, 2009

Filed:

Nov 5, 2008

Appl. No.:

12/291066

Inventors:

John Girdner Atwood - West Redding CT, US
Albert Carmelo Mossa - Trumbull CT, US
Lisa May Goven - Bridgeport CT, US
Fenton Williams - Brookfield CT, US
Timothy M. Woudenberg - Bethel CT, US
Marcel Margulies - Scarsdale NY, US
Robert P. Rahusa - Newton CT, US
Richard Leath - Berkley CA, US
Clive Miles - San Rafael CA, US

Assignee:

Applied Biosystems Inc. - Foster City CA

International Classification:

C12Q 3/00
C12M 1/02

US Classification:

435 3, 4352861

Abstract:

A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.

US Patent:

54756103, Dec 12, 1995

Filed:

Apr 20, 1992

Appl. No.:

7/871264

Inventors:

John G. Atwood - West Redding CT
Albert C. Mossa - Trumbull CT
Lisa M. Goven - Bridgeport CT
Fenton Williams - Brookfield CT
Timothy M. Woudenberg - Bethel CT
Robert P. Ragusa - Newton CT
Richard Leath - Berkley CA
Clive Miles - San Rafael CA

Assignee:

The Perkin-Elmer Corporation - Norwalk CT

International Classification:

G06G 758

US Classification:

364500

Abstract:

An instrument for performing highly accurate PCR employing a sample block in microtiter tray format. The sample block has local balance and local symmetry. A three zone film heater controlled by a computer and ramp cooling solenoid valves also controlled by the computer for gating coolant flow through the block controls the block temperature. Constant bias cooling is used for small changes. Sample temperature is calculated instead of measured. A platen deforms plastic caps to apply a minimum acceptable threshold force for seating the tubes and thermally isolates them. A cover isolates the block. The control software includes diagnostics. An install program tests and characterizes the instrument. A new user interface is used. Disposable, multipiece plastic microtiter trays to give individual freedom to sample tubes are taught.