Alekha Kumar Dash

Address:

13518 Sahler St, Omaha, NE 68164

VIN:

4A3AK24F87E009466

Make:

MITSUBISHI

Model:

ECLIPSE

Year:

2007

US Patent:

8242165, Aug 14, 2012

Filed:

Oct 26, 2007

Appl. No.:

12/311479

Inventors:

Alekha K. Dash - Omaha NE, US
William J. Trickler - Omaha NE, US

Assignee:

Creighton University - Omaha NE

International Classification:

A61K 31/335
A61K 47/00
A61K 31/70

US Classification:

514449, 514 27, 514777

Abstract:

The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer therapeutic agent, such as gemcitabine, taxanes, and hydrophobic cancer therapeutic agents). Also disclosed are methods for preparing such nanoparticles and pharmaceutical compositions, as well as methods for treating breast, pancreatic, colon, prostate, and other cancers by parenterally, intravenously, or otherwise administering such nanoparticles and pharmaceutical compositions.

US Patent:

6767550, Jul 27, 2004

Filed:

Jun 30, 2000

Appl. No.:

09/608488

Inventors:

Ping Luo - Berkeley CA
Alekha K. Dash - Omaha NE

Assignee:

Berkeley Advanced Biomaterials, Inc. - Berkeley CA

International Classification:

A61K 920

US Classification:

424426, 424422, 424423, 424424, 424425, 424464, 424472, 424489

Abstract:

A hydroxyapatite based bioresorbable material is incorporated with anti-cancer agents to form an implant used for treatment against cancer. Sustained release of the anti-cancer agents may be achieved after implantation at the targeted sites. The dosage of the anti-cancer agent, the microstructure, morphology, and composition of the bioresorbable material allow control of the release profile. The invented implant may be used for drug delivery, chemotherapy, or gene therapy.

US Patent:

20200064247, Feb 27, 2020

Filed:

Mar 13, 2017

Appl. No.:

15/457730

Inventors:

- Omaha NE, US
Alekha Dash - Omaha NE, US

International Classification:

G01N 13/00
G01N 33/15

Abstract:

A method of performing a diffusion test includes clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane is exposed to ambient air, flowing a substance through the ambient air such that at least a portion of the substance lands on the second surface while the membrane is vertically oriented, and determining a concentration of the substance in the interior chamber after some of the substance has diffused through the membrane.

US Patent:

20180243419, Aug 30, 2018

Filed:

Feb 20, 2018

Appl. No.:

15/900526

Inventors:

- Omaha NE, US
Alekha Dash - Omaha NE, US
Michael Nichols - Omaha NE, US
David Smith - Omaha NE, US

International Classification:

A61K 41/00
A61K 47/54
A61K 47/69
A61K 49/00

Abstract:

Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a peptide with a photosensitizer attached to one end of peptide chain, providing binding to liposomes and their permeabilization upon light illumination.