Aleksandr K Rabinovich

US Patent:

58613986, Jan 19, 1999

Filed:

Aug 26, 1996

Appl. No.:

8/703025

Inventors:

Aleksandr K. Rabinovich - La Jolla CA
Dale S. Dhanoa - Del Mar CA
David R. Luthin - San Diego CA
Richard A. Bychowski - Cardiff CA
Dilip R. Bhumralkar - San Diego CA

Assignee:

Alanex Corporation - San Diego CA

International Classification:

C07D40302
A61K 31495

US Classification:

514250

Abstract:

Benzo(e)perimidine-4-carboxamide derivatives of general structural formula I ##STR1## (where R. sub. a, R. sup. 1, R. sup. 2, R. sup. 3, R. sup. 4, R. sup. 5, and R. sup. 6 are as defined in the specification) have activity for receptors of corticotropin releasing factor (CRF). The compounds are useful in treating stress-related diseases, cardiovascular, neurological and psychiatric disorders including anxiety, depression, eating disorders, anorexia nervosa, superanuclear palsy, irritable bowel syndrome, gastrointestinal diseases, immune suppression, inflammatory disorders, drug and alcohol withdrawal symptoms, drug addiction, Alzheimer's disease or fertility disorders.

US Patent:

20180002378, Jan 4, 2018

Filed:

Jan 6, 2016

Appl. No.:

15/540460

Inventors:

- Hoofddorp, NL
Guangcheng JIANG - San Diego CA, US
Aleksandr K. RABINOVICH - La Jolla CA, US

International Classification:

C07K 7/06
A61K 38/00

Abstract:

This disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof: in which m, p, A, Ar, Ar, Ar, R, R, and Rare defined in the specification. The compounds of formula (I) can be used as CGRP antagonists and can be used to treat