Alessandra Moretti

US Patent:

8323909, Dec 4, 2012

Filed:

Apr 29, 2010

Appl. No.:

12/770597

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Lizhu Lin - La Jolla CA, US
Ken Chien - La Jolla CA, US
Alessandra Moretti - La Jolla CA, US
Karl Laugwitz - La Jolla CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 5/00
G01N 33/53

US Classification:

435 71, 435375, 435377

Abstract:

The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.

US Patent:

20060246446, Nov 2, 2006

Filed:

Feb 2, 2004

Appl. No.:

10/544053

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Chenleng Cai - San Diego CA, US
Alessandra Moretti - La Jolla CA, US
Kenneth Chien - La Jolla CA, US
Karl-Ludwig Laugwitz - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C12Q 1/68
G01N 33/567
C12N 5/08

US Classification:

435006000, 435007200, 435366000

Abstract:

The present invention provides in vitro methods of expansion and propagation of undifferentiated progenitor cells and more specifically undifferentiated progenitor cells containing Islet1, a marker apparently unique to proliferating cardiac stem cells. Methods are described for isolation of stem cell populations as well as for provoking expansion and propagation of undifferentiated progenitor cells without differentiation, to provide cardiac repair or improve cardiac function, for example.

US Patent:

20080108090, May 8, 2008

Filed:

May 2, 2007

Appl. No.:

11/799839

Inventors:

Sylvia Evans - Del Mar CA, US
Ju Chen - San Diego CA, US
Lizhu Lin - La Jolla CA, US
Ken Chien - La Jolla CA, US
Alessandra Moretti - La Jolla CA, US
Karl Laugwitz - La Jolla CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 33/53

US Classification:

435 721

Abstract:

The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor cells using a GSK-3β inhibitor.