Alex Chen

US Patent:

7629470, Dec 8, 2009

Filed:

Jul 1, 2005

Appl. No.:

11/629005

Inventors:

Kevin R. Campos - Berkeley Heights NJ, US
Artis Klapars - Scotch Plains NJ, US
J. Christopher McWilliams - Hoboken NJ, US
C. Scott Shultz - Maplewood NJ, US
Debra J. Wallace - Scotch Plains NJ, US
Alex M. Chen - Metuchen NJ, US
Lisa F. Frey - Somerset NJ, US
Andrey V. Peresypkin - Cranford NJ, US
Yaling Wang - Westfield NJ, US
Robert M. Wenslow - Cream Ridge NJ, US
Cheng-Yi Chen - Plainsboro NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 213/63

US Classification:

546290

Abstract:

The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).

US Patent:

20070021430, Jan 25, 2007

Filed:

Sep 17, 2004

Appl. No.:

10/570409

Inventors:

Alex Chen - Metuchen NJ, US
Robert Wenslow - Ream Ridge NJ, US

International Classification:

A61K 31/498
C07D 487/04

US Classification:

514249000, 544350000

Abstract:

The present invention relates to a novel crystalline anhydrate polymorph of the dihydrogenphosphate salt of (2R)-4-oxo-4-[3-trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a process for their preparation, pharmaceutical compositions containing this novel form, and methods of use of the novel form and pharmaceutical compositions for the treatment of diabetes, obesity, and high blood pressure.

US Patent:

20090131465, May 21, 2009

Filed:

Oct 27, 2008

Appl. No.:

12/290062

Inventors:

Alex M. Chen - Edison NJ, US
Jennifer R. Foley - Garwood NJ, US
John Limanto - Rahway NJ, US
Robert M. Wenslow - Cream Ridge NJ, US
Karen C. Thompson - Lansdale PA, US
Andrey V. Peresypkin - Cambridge MA, US

International Classification:

A61K 31/438
C07D 401/06
A61P 3/04
A61P 3/10
A61P 15/10

US Classification:

514278, 546 17

Abstract:

The present invention relates to a process for producing crystalline N-[1-((3R)-1′-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-yl]carbonyl}-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)-1-methylethyl]acetamide, and novel salts, solvates, hydrates and polymorphs thereof.

US Patent:

20090270477, Oct 29, 2009

Filed:

Oct 29, 2007

Appl. No.:

12/446996

Inventors:

Jeffrey T. Kuethe - Somerset NJ, US
Alex M. Chen - Edison NJ, US

International Classification:

A61K 31/4035
C07D 209/44

US Classification:

514412, 548515

Abstract:

This application is directed to a novel polymorph of a hydroisoindoline tachykinin receptor antagonist having the following structural formula A.

US Patent:

20100041893, Feb 18, 2010

Filed:

Oct 22, 2009

Appl. No.:

12/603901

Inventors:

KEVIN R. CAMPOS - Berkeley Heights NJ, US
Artis Klapars - Scotch Plains NJ, US
J. Christopher McWilliams - Hoboken NJ, US
C. Scott Shultz - Maplewood NJ, US
Debra J. Wallace - Scotch Plains NJ, US
Alex M. Chen - Metuchen NJ, US
Lisa F. Frey - Somerset NJ, US
Andrey V. Peresypkin - Cranford NJ, US
Yaling Wang - Westfield NJ, US
Robert M. Wenslow - Cream Ridge NJ, US
Cheng-Yi Chen - Plainsboro NJ, US

International Classification:

C07D 211/72
C07C 233/00

US Classification:

546300, 564123

Abstract:

The present invention is directed to a practical process for the preparation of an enamide (II) by palladium catalyzed coupling of a primary amide (IV) with a compound of structural formula (III), as shown below: As well as to crystalline forms of a compound produced by this process, in particular, an anhydrous crystal form, Form B, and crystalline solvates falling into three patterns, Type 1, Type 2, and Type 3, and crystalline intermediate compounds produced in the process. Still further, the present invention relates to the stereoselective reduction of the tetrasubstituted enamide (II) to the corresponding amide (I).

US Patent:

20210128934, May 6, 2021

Filed:

Oct 28, 2020

Appl. No.:

17/082084

Inventors:

ALEX CHIA-HWANG CHEN - Johns Creek GA, US
Zhaozhang Wang - Tainan City, TW

Assignee:

PhotonFECT Technology, LLC - Johns Creek GA

International Classification:

A61N 5/06

Abstract:

Based on traditional Chinese medicine and ancient Eight-Trigram theory, a wearable five-color phototherapy device is invented for a unique painless, drug-free, non-invasive, and true green organic therapy by using light energy on some particular areas of a person's skin. There are multiple light-emitting components which is a number of light-emitting elements arranged in each of Eight-Trigram positions are designed on the bottom of this device. These multiple light-emitting components produce color of red or green or white or yellow or black or no color in each of Eight-Trigram positions. A software or App is developed to directly or remotely control and communicate with such device and provide the optimal solution for the five-color phototherapy.

Address:

5507 Reflections Blvd, Lutz, FL 33558

VIN:

2HJYK16597H506451

Make:

HONDA

Model:

RIDGELINE

Year:

2007