Alexander F Lin

US Patent:

20140002075, Jan 2, 2014

Filed:

Nov 28, 2011

Appl. No.:

13/988813

Inventors:

Alexander Lin - Newton MA, US
Carolyn Mountford - East Ryde NSW, AU
Saadallah Ramadan - Bexley, AU
Robert Stern - Boston MA, US

International Classification:

G01R 33/483

US Classification:

324308

Abstract:

A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.

US Patent:

20200191891, Jun 18, 2020

Filed:

Aug 10, 2017

Appl. No.:

16/324193

Inventors:

- Cambridge MA, US
- Boston MA, US
Alexander P. Lin - Boston MA, US

International Classification:

G01R 33/46

Abstract:

A method and a system for analysis of raw MRS data, in the form of signal strength versus chemical shift (ppm), from multiple scanners, includes “signal estimation” from each raw data set, followed by cross-scanner “data harmonization” of results. The final resulting MRS signals are consistent from one scanner to another, and are used for analysis by radiologists and other physicians.

US Patent:

20170172495, Jun 22, 2017

Filed:

Mar 18, 2015

Appl. No.:

15/127377

Inventors:

- Callaghan, New South Wales, AU
Saadallah Ramadan - Bexley NSW, AU
Alexander Lin - Boston MA, US

International Classification:

A61B 5/00
G01R 33/48
G01R 33/46
A61B 5/055

Abstract:

The present invention relates to a method and system for using neurochemical markers to identify different types of pain, including chronic and acute, and providing the capacity to monitor response to therapy on an individual basis. The present invention relates to a method and system for using neuro biomarkers to identify pain of different types and origins, and the capacity to monitor response to therapy on a personalized basis.