Alexander Mills Wood

US Patent:

7402603, Jul 22, 2008

Filed:

Nov 5, 2002

Appl. No.:

10/494221

Inventors:

Ying-Nan Pan Chen - Parsippany NJ, US
Peter Lassota - Succasunna NJ, US
Alexander Wallace Wood - Ho Ho Kus NJ, US

Assignee:

Novartis AG - Basel

International Classification:

A61K 31/405

US Classification:

514415

Abstract:

The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e. g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

US Patent:

20050043409, Feb 24, 2005

Filed:

Oct 24, 2002

Appl. No.:

10/493297

Inventors:

Ying-Nan Chen - Parsippany NJ, US
Peter Lassota - Succasunna NJ, US
Alexander Wood - Ho Ho Kus NJ, US

International Classification:

A61K031/195

US Classification:

514567000

Abstract:

A combination therapy for treating patients suffering from pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, is disclosed. The patient is treated concurrently with a cycloocygenase-2 inhibitor and at least one compound selected from the group consisting of a microtubule interfering agent, an epithelial growth factor receptor tyrosine protein kinase inhibitor and a vascular endothelial growth factor receptor tyrosine kinase inhibitor.

US Patent:

20080227845, Sep 18, 2008

Filed:

May 20, 2008

Appl. No.:

12/123846

Inventors:

Ying-Nan Pan Chen - Parsippany NJ, US
Peter Lassota - Succasunna NJ, US
Alexander Wallace Wood - Ho Ho Kus NJ, US

International Classification:

C07D 209/04
A61K 31/195
C07C 63/00
A61P 35/00
A61K 31/404

US Classification:

514415, 514567, 562405, 548503

Abstract:

The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

US Patent:

20090192211, Jul 30, 2009

Filed:

Apr 7, 2009

Appl. No.:

12/419679

Inventors:

Ying-Nan Pan Chen - Parsippany NJ, US
Peter Lassota - Succasunna NJ, US
Alexander Wallace Wood - Ho Ho Kus NJ, US

International Classification:

A61K 31/404
A61P 35/00

US Classification:

514415

Abstract:

The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor (“COX-2 inhibitor”) and (b) a histone deacetylase inhibitor (“HDAI”) for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.

US Patent:

20110046190, Feb 24, 2011

Filed:

Nov 3, 2010

Appl. No.:

12/938868

Inventors:

Ying-Nan Pan CHEN - Parsippany NJ, US
Peter Lassota - Succasunna NJ, US
Alexander Wallace Wood - Ho Ho Kus NJ, US

International Classification:

A61K 31/427
A61P 35/00
A61P 1/00

US Classification:

514365

Abstract:

A combination therapy for treating patients suffering from pre-malignant colon lesions (e.g. polyps) and colon cancer, as well as other malignancies, is disclosed. The patient is treated concurrently with a cycloocygenase-2 inhibitor and at least one compound selected from the group consisting of a microtubule interfering agent, an epithelial growth factor receptor tyrosine protein kinase inhibitor and a vascular endothelial growth factor receptor tyrosine kinase inhibitor.