Alexander H Yang

US Patent:

20220361871, Nov 17, 2022

Filed:

Aug 1, 2022

Appl. No.:

17/878406

Inventors:

- Boston MA, US
Alexander Yang - Boston MA, US
Kyle C. Wu - Boston MA, US
Robert W. Crum - Brookline MA, US
Farokh R. Demehri - Brookline MA, US
Brianna L. Slatnick - Cambridge MA, US

International Classification:

A61B 17/062
A61B 17/04

Abstract:

Needle drivers and methods of the present disclosure are generally directed at intracorporeal suture tying using a winding technique. For example, a needle driver may include an elongate shaft having a magnet section between a proximal section and a distal section. A clamp coupled to the distal section may grasp a first end portion of a suture. A needle coupled to a second end portion of the suture may be magnetically secured to the magnet section, and the magnet section may then be rotated to form a loop in the suture. Forming a knot in the suture may include moving the loop over the first end portion of the suture grasped in the clamp. As compared to other intracorporeal suture tying techniques, intracorporeal knot tying carried out using the needle drivers and methods of the present disclosure may reduce the time and complexity associated with laparoscopic procedures.

US Patent:

20230036914, Feb 2, 2023

Filed:

Oct 12, 2022

Appl. No.:

17/964175

Inventors:

- Boston MA, US
Heung Bae Kim - Weston MA, US
Brianna L. Slatnick - Cambridge MA, US
Robert W. Crum - Brookline MA, US
Kyle C. Wu - Boston MA, US
Alexander Yang - Boston MA, US
Steven J. Fishman - Weston MA, US

International Classification:

A61G 7/00
A61G 7/05

Abstract:

A proning device includes a conformable structure that adapts to the shape of a subject, surrounded by a shell that imparts a substantially elliptical cross-sectional shape to an exterior of the device to facilitate rotation of the subject within the device when the device is wrapped around the subject. A low-friction interface may also be provided to further facilitate rotation of the subject. The device advantageously reduces staffing needs for proning a subject while facilitating extended proning and periodic re-orientation of the subject. Also disclosed herein are methods for making and using such a proning device.

US Patent:

20200392191, Dec 17, 2020

Filed:

Jul 10, 2020

Appl. No.:

16/925848

Inventors:

- Pleasanton CA, US
Tim CRAIG - Mountain View CA, US
Alexander YANG - Mountain View CA, US
Liv JENSEN - Mountain View CA, US
Charlotte YANG - Mountain View CA, US
Corissa HARRIS - Mountain View CA, US
Matthew DIPIETRO - Gilroy CA, US
Dhruti DALAL - Sunnyvale CA, US

Assignee:

Roche Sequencing Solutions, Inc. - Pleasanton CA

International Classification:

C07K 14/245
C12Q 1/6874
C12Q 1/68
G01N 33/68
C12N 9/12

Abstract:

The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.

US Patent:

20200216887, Jul 9, 2020

Filed:

Jan 20, 2017

Appl. No.:

16/071406

Inventors:

- Santa Clara CA, US
- Mannheim, DE
Alexander H. Yang - Campbell CA, US
Liv E. Jensen - Palo Alto CA, US
Marshall Porter - Santa Clara CA, US
Charlotte Yang - San Jose CA, US
Corissa Harris - Santa Clara CA, US
Matt Dipetro - Gilroy CA, US

Assignee:

Genia Technologies, Inc. - Santa Clara CA

International Classification:

C12Q 1/6869
C12N 9/12

Abstract:

A method is provided for preparing nanopore sequencing complexes in membranes for sequencing of polymers, e.g., polynucleotides and polypeptides. The nanopore sequencing complex is formed by the sequential linking of an enzyme to a nanopore that is inserted in a membrane, and of a polymer to the enzyme. Alternatively, the nanopore sequencing complex is formed by linking a preformed enzyme-polymer complex to a nanopore that is inserted in a membrane. The enzyme polymer complex is interchangeable.

US Patent:

20180362594, Dec 20, 2018

Filed:

Sep 20, 2016

Appl. No.:

15/762092

Inventors:

- Santa Clara CA, US
Tim CRAIG - Mountain View CA, US
Alexander YANG - Mountain View CA, US
Liv JENSEN - Mountain View CA, US
Charlotte YANG - Mountain View CA, US
Corissa HARRIS - Mountain View CA, US

Assignee:

GENIA TECHNOLOGIES, INC. - Santa Clara CA

International Classification:

C07K 14/245
C12N 9/12
C12Q 1/6874

Abstract:

The present disclosure provides variant OmpG polypeptides, compositions comprising the OmpG variant polypeptides, and methods for using the variant OmpG polypeptides as nanopores for determining the sequence of single stranded nucleic acids. The variant OmpG nanopores reduce the ionic current noise versus the parental OmpG polypeptide from which they are derived and thereby enable sequencing of polynucleotides with single nucleotide resolution. The reduced ionic current noise also provides for the use of these OmpG nanopore variants in other single molecule sensing applications, e.g., protein sequencing.