Alexei L Brooun from 12584 Montellano Ter, San Diego, CA 92130, age 54, Phone: 6193842289

Vehicle Records

Alexei Brooun
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Address:

12584 Montellano Ter, San Diego, CA 92130
Phone:

6193842289
VIN:

JTDKN3DU3C5375476
Make:

TOYOTA
Model:

PRIUS
Year:

2012

Us Patents

Crystallization Of Glucocorticoid Receptor
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US Patent:

7241868, Jul 10, 2007
Filed:

Oct 6, 2004
Appl. No.:

10/960642
Inventors:

Alexei Brooun - San Diego CA, US
Oleg Brodsky - San Diego CA, US
Ellen Chien - La Jolla CA, US
Douglas R. Dougan - Calgary, CA
Clifford D. Mol - San Diego CA, US
Gyorgy Snell - Richmond CA, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

C07K 14/00
US Classification:

530350
Abstract:

Provided are crystals relating to human Glucocorticoid Receptor and its various uses.

Crystallization Of Mvas (Hmg-Coa Synthase)
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US Patent:

7252930, Aug 7, 2007
Filed:

Jan 14, 2004
Appl. No.:

10/758291
Inventors:

Alexei Brooun - San Diego CA, US
David J. Hosfield - San Diego CA, US
Robert J. Skene - San Diego CA, US
Leslie W. Tari - San Diego CA, US
Sheng Ye - Allen TX, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

C12Q 1/00
C12N 9/88
US Classification:

435 4, 435232
Abstract:

Provided are crystals relating to MvaS (HMG-CoA Synthase) and its various uses.

Crystallization Of Protein Kinase Bα/Akt1
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US Patent:

7309594, Dec 18, 2007
Filed:

May 10, 2004
Appl. No.:

10/842966
Inventors:

Alexei Brooun - San Diego CA, US
Ellen Y. T. Chien - La Jolla CA, US
Douglas R. Dougan - Calgary, CA
Andrew J. Jennings - La Jolla CA, US
Michelle L. Kraus - Temecula CA, US
Clifford D. Mol - San Diego CA, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

C12N 9/12
US Classification:

435194
Abstract:

Provided are crystals relating to Protein kinase Bα/AKT1 and its various uses.

Crystallization Of The Catalytic Domain Of Human Phosphodiesterase 4-D3 (Pde4-D3)
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US Patent:

7556950, Jul 7, 2009
Filed:

Apr 29, 2004
Appl. No.:

10/836040
Inventors:

Alexei Brooun - San Diego CA, US
Ellen Chien - La Jolla CA, US
Douglas R. Dougan - Calgary, CA
Michelle L. Kraus - Temecula CA, US
Clifford D. Mol - San Diego CA, US
Gyorgy Snell - Richmond CA, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

C12N 9/16
C12N 9/00
US Classification:

435196, 435183, 436 4
Abstract:

Provided are crystals relating to human phosphodiesterase 4-D3 (PDE4-D3), methods for forming crystals comprising PDE4-D3 and crystals comprising PDE4-D3 co-crystallized with a ligand molecule, and methods of using crystals comprising PDE4-D3.

Crystalline Composition Of Farsenyl Pyrophosphate Synthase (Ispa)
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US Patent:

7563610, Jul 21, 2009
Filed:

Aug 28, 2003
Appl. No.:

10/651668
Inventors:

Alexei Brooun - San Diego CA, US
Douglas R. Dougan - Calgary, CA
David Hosfield - San Diego CA, US
Yanming Zhang - Tallahassee FL, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

C12N 9/12
C12N 9/00
US Classification:

435194, 435183, 436 4
Abstract:

Provided are crystals relating to Farsenyl Pvrophosphate Synthase (IspA) from and its various uses.

Crystal Structure Of A Receptor-Ligand Complex And Methods Of Use
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US Patent:

20080020984, Jan 24, 2008
Filed:

Jul 23, 2007
Appl. No.:

11/781738
Inventors:

Peter Kuhn - Solana Beach CA, US
Anand Kolatkar - San Diego CA, US
Alexei Brooun - San Diego CA, US
Jill Chrencik - San Diego CA, US
Michelle Kraus - Temecula CA, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

G06G 7/48
A61K 38/00
C07K 1/00
C07K 14/00
C40B 30/04
G01N 33/00
US Classification:

514013000, 436086000, 506009000, 530325000, 530345000, 703011000
Abstract:

The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.

Crystal Of A Receptor-Ligand Complex And Methods Of Use
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US Patent:

20080064052, Mar 13, 2008
Filed:

Jan 12, 2007
Appl. No.:

11/622785
Inventors:

Peter Kuhn - Solana Beach CA, US
Alexei Brooun - San Diego CA, US
Jill Chrencik - San Diego CA, US
Michelle Kraus - Temecula CA, US
Assignee:

The Scripps Research Institute - La Jolla CA
International Classification:

G01N 33/00
C07K 1/00
G06G 7/48
US Classification:

435007920, 530350000, 703011000
Abstract:

The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug screening and drug design processes. Thus, the invention also relates to methods for utilizing the crystal structure of the Receptor-Ligand Complex for identifying, designing, selecting, or testing inhibitors of the EphB4 receptor protein, such inhibitors being useful as therapeutics for the treatment or modulation of i) diseases; ii) disease symptoms; or iii) the effect of other physiological events mediated by the receptor.

Crystal Structure Of Mvas
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US Patent:

7076372, Jul 11, 2006
Filed:

Jan 14, 2004
Appl. No.:

10/757963
Inventors:

Alexei Brooun - San Diego CA, US
David J. Hosfield - San Diego CA, US
Robert J. Skene - San Diego CA, US
Leslie W. Tari - San Diego CA, US
Sheng Ye - Allen TX, US
Assignee:

Takeda San Diego, Inc. - San Diego CA
International Classification:

G01N 33/48
G06G 19/00
US Classification:

702 19, 703 11
Abstract:

Provided are structure coordinates relating to MvaS and its various uses.

Resumes

Director, Target Protein Design

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Location:

San Diego, CA

Industry:

Pharmaceuticals

Work:

Pfizer Jan 2007 - Aug 2018
Associate Research Fellow
Merck Jan 2007 - Aug 2018
Director, Target Protein Design
The Scripps Research Institute Jun 2004 - Dec 2006
Scientific Associate
Syrrx Jan 2001 - Jan 2004
Senior Scientist

Skills:

Drug Discovery
Drug Development
Protein Chemistry
Medicinal Chemistry
Protein Purification
Pharmaceutical Industry
Molecular Biology
Clinical Development
Biochemistry
Drug Design
Assay Development
Cell Biology
Life Sciences