Alison P Joyce

US Patent:

20060240488, Oct 26, 2006

Filed:

Mar 23, 2006

Appl. No.:

11/388030

Inventors:

John Nowak - Stratham NH, US
Denise O'Hara - Reading MA, US
John Cryan - Shrewsbury MA, US
Teresa Caiazzo - Tewksbury MA, US
Alison Joyce - Groveland MA, US
Joseph Rajewski - South Boston MA, US
Shujun Sun - Brentwood NH, US
Neil Wolfman - Dover MA, US

International Classification:

G01N 33/53

US Classification:

435007500, 435007930

Abstract:

This disclosure provides methods for the detection of antibodies to a GDF-8 modulating agent such as, e.g., MYO-029, in a biological sample. Methods to detect an immune response to a GDF-8 modulating agent are also included. In particular, methods to assess an immune response in animals, including humans, to a GDF-8 modulating agent such as a GDF-8 inhibitor are provided herein.

US Patent:

20050074901, Apr 7, 2005

Filed:

Feb 13, 2003

Appl. No.:

10/367505

Inventors:

John Castracane - Groton MA, US
Alison Joyce - Groveland MA, US
Thomas Miller - East Boston MA, US
Fred Reynolds - Waltham MA, US

International Classification:

G01N033/543

US Classification:

436518000

Abstract:

Methods, assays, and kits for detecting the presence of PIG3 in human cell extracts, serum, plasma, other body fluids and extra-cellular tissue culture media to determine valuable prognostic, monitoring and diagnostic information about the status of a patient. The methods are rapid and quantitative and can be used to evaluate the viability of cells and tissue, to evaluate progress of a disease and/or its treatment, to evaluate the cytotoxicity of unknown compounds and to study the kinetics of cell death.