Alison O'Neill - Boston MA, US Douglas B. Jacoby - Wellesley MA, US Abdellah Sentissi - Dover MA, US Kamala Kesavan - West Roxbury MA, US E. Michael Egan - Brookline MA, US Laura Sen - Brookline MA, US
The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
Systemic Administration Of Chlorotoxin Agents For The Diagnosis And Treatment Of Tumors
The present invention is directed to methods and compositions for the treatment and diagnosis of neoplastic tumors. The inventive methods generally include systemic (e.g., intravenous) administration of a chloroxotoxin agent that may or may not be labeled.
Alison O'Neill - Cambridge MA, US Douglas B. Jacoby - Wellesley MA, US Abdellah Sentissi - Dover MA, US Kamala Kesavan - West Roxbury MA, US Laura Sen - Brookline MA, US
The present invention is directed to methods and methods for the treatment, inhibition and/or reduction, and detection of metastatic tumors. In some embodiments, the inventive methods include systemic (e.g., intravenous) administration of a chlorotoxin agent that may or may not be labeled. In some embodiments, the inventive methods allow treatment, inhibition and/or reduction, and detection of metastases in the brain. In some embodiments, neovascularization is inhibited and/or newly formed vessels are caused to regress.
Methods Of Treating Cancer With An Anti-Cd39 Antibody
The invention provides methods of treating cancer using an anti-CD39 antibody or fragment thereof as monotherapy or in combination with other therapies at particular dosages and frequencies.
- Cambridge MA, US Andrew LAKE - Westwood MA, US Michael WARREN - North Chelmsford MA, US Austin DULAK - Reading MA, US Erik DEVEREAUX - Hanover MA, US Pamela M. HOLLAND - Belmont MA, US Tauqeer ZAIDI - Sharon MA, US Matthew RAUSCH - Cambridge MA, US Bianka Prinz - Lebanon NH, US Nels P. NIELSON - Lebanon NH, US Sonia DAS - Cambridge MA, US Alison M. O'Neill - Cambridge MA, US
Assignee:
Surface Oncology, Inc. - Cambridge MA
International Classification:
C07K 16/28 A61P 35/00
Abstract:
The invention provides anti-CD39 antibody compositions and their use in treating cancer. In some embodiments, an isolated anti-CD39 antibody is provided. Such an isolated anti-CD39 antibody binds to human CD39, wherein the antibody is optionally fully human or humanized. In some embodiments, the disclosure provides a method of enhancing, increasing and/or sustaining an anti-tumor immune response in a subject comprising administering the antibody or composition described herein to a subject having a tumor.
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