Alison Mary Skinner

US Patent:

49590693, Sep 25, 1990

Filed:

Oct 20, 1989

Appl. No.:

7/424622

Inventors:

Karl W. Brennan - Somerset NJ
Alison M. Skinner - Long Valley NJ
Gregory Weaver - New Hope PA

Assignee:

Ethicon, Inc. - Somerville NJ

International Classification:

A61B 1700

US Classification:

606228

Abstract:

A braided surgical suture is provided which in a first embodiment is woven in a spiral braid. The suture is braided by moving thread carriers from position to position around a circular path. As each carrier moves it moves from its present position to a succeeding position which is at least two positions removed from its present position. Such spiral braided sutures are advantageously produced without core filaments, providing benefits in strength, smoothness, pliability and cylindrical uniformity without the discontinuity of properties characteristic of conventionally braided cored sutures. In a second embodiment the suture is woven in a lattice braid, providing a plurality of distributed core passageways for individual core fibers.

US Patent:

20210148890, May 20, 2021

Filed:

Jan 6, 2021

Appl. No.:

17/142761

Inventors:

- Oxford, GB
Adrian Marc Simon Jacobs - Oxford, GB
Jason Roderick Hector - Oxford, GB
Michael James Brownlow - Oxfordshire, GB
Masahiro Adachi - Osaka, JP
Alison Mary Skinner - Mansfield MA, US
Mark Childs - Formby Merseyside, GB

International Classification:

G01N 33/49
C12Q 1/6844
B01L 3/00

Abstract:

A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.

US Patent:

20170056887, Mar 2, 2017

Filed:

Aug 28, 2015

Appl. No.:

14/838797

Inventors:

- Osaka, JP
- Falmouth MA, US
Jason Roderick Hector - Oxford, GB
Michael James Brownlow - Oxfordshire, GB
Masahiro Adachi - Osaka, JP
Alison Mary Skinner - Mansfield MA, US
Mark Childs - Formby Merseyside, GB

International Classification:

B01L 3/00

Abstract:

A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.

US Patent:

20170059523, Mar 2, 2017

Filed:

Aug 28, 2015

Appl. No.:

14/838781

Inventors:

- Osaka, JP
Adrian Marc Simon Jacobs - Oxford, GB
Jason Roderick Hector - Oxford, GB
Michael James Brownlow - Oxfordshire, GB
Masahiro Adachi - Osaka, JP
Alison Mary Skinner - Mansfield MA, US
Mark Childs - Formby Merseyside, GB

International Classification:

G01N 27/447
C12Q 1/68
G01N 33/49
B01L 3/00

Abstract:

A method of determining the result of an assay in a microfluidic device includes the steps of: dispensing a sample droplet onto a first portion of an electrode array of the microfluidic device; dispensing a reagent droplet onto a second portion of the electrode array of the microfluidic device; controlling actuation voltages applied to the electrode array to mix the sample droplet and the reagent droplet into a product droplet; sensing a dynamic property of the product droplet; and determining an assay of the sample droplet based on the sensed dynamic property. The dynamic property is a physical property of the product droplet that influences a transport property of the product droplet on the electrode array. Example dynamic properties of the product droplet include the moveable state, split-able state, and viscosity based on droplet properties. The method may be used to perform an amoebocyte lysate (LAL) assay.