Allan J Doctor

US Patent:

20210330754, Oct 28, 2021

Filed:

Apr 23, 2021

Appl. No.:

17/238809

Inventors:

- Baltmore MD, US
Allan Doctor - Towson MD, US
Phil Spinella - Chesterfiled MO, US

International Classification:

A61K 38/42
A61K 9/127
A61K 47/24
A61K 47/28
C07F 9/10
A61K 9/19

Abstract:

Synthetic blood substitutes and methods for making them. A lipid-amphiphile blood-substitute precursor compound having a hydrophobic fatty acid/acyl moiety, a hydrophilic head moiety including a phosphate group, and a pH responsive moiety. The lipid-amphiphile precursor is configured to self-assemble from a solution mixture of phospholipid and cholesterol in the presence of hemoglobin and an allosteric effector into a hybrid-vesicle resulting from the combined self-assembly of both the amphiphilic lipid-oligomer and the lipids into an advanced vesicular structure containing a hemoglobin/allosteric effector payload.