Allan J Robins

US Patent:

7737253, Jun 15, 2010

Filed:

Jun 18, 2007

Appl. No.:

11/764752

Inventors:

Allan J. Robins - Athens GA, US
Thomas C. Schulz - Athens GA, US

Assignee:

BresaGen, Inc. - Athens GA

International Classification:

C07K 14/00
C12N 15/85

US Classification:

530350, 435455

Abstract:

The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a tumor, and for the treatment of various cancers. The invention also provides antibodies that specifically recognize the disulfide linked Erbb2Δ16 homodimer, an Erbb2Δ16/Erbb3 heterodimer, or post-translational modifications of Erbb2 that are specific to Erbb2 of variant hESCs. In addition, the invention provides a modified defined media useful in the absence of a feeder layer and in the absence of serum or serum replacement, that comprises a basal salt nutrient solution, bFGF, IGF-I, and Activin A, and wherein the composition does not comprise heregulin. The invention further relates to the use of an Erbb2 variant isoform to generate robust cell cultures that are independent of heregulin.

US Patent:

8008075, Aug 30, 2011

Filed:

Nov 4, 2008

Appl. No.:

12/264760

Inventors:

Chad Green - San Diego CA, US
Xiaojie Yu - Irvine CA, US
Anne Bang - San Diego CA, US
Eugene Brandon - San Diego CA, US
Olivia Kelly - San Diego CA, US
Alan D. Agulnick - San Diego CA, US
E. Edward Baetge - Encinatas CA, US
Kevin A. D'Amour - San Diego CA, US
Thomas C. Schulz - Athens GA, US
Allan J. Robins - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/071

US Classification:

435377, 435383, 435384, 435366, 435375

Abstract:

The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.

US Patent:

8153429, Apr 10, 2012

Filed:

Feb 23, 2007

Appl. No.:

11/678487

Inventors:

Allan J. Robins - Athens GA, US
Thomas C. Schulz - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02

US Classification:

435404, 435405, 435325

Abstract:

The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.

US Patent:

8211699, Jul 3, 2012

Filed:

Aug 13, 2007

Appl. No.:

11/838054

Inventors:

Allan J. Robins - Athens GA, US
Thomas C. Schulz - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02

US Classification:

435383, 435405, 435325, 435404, 435384

Abstract:

The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.

US Patent:

8334138, Dec 18, 2012

Filed:

Aug 15, 2010

Appl. No.:

12/856662

Inventors:

Allan J Robins - Athens GA, US
Thomas C Schulz - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/10
C12N 5/071

US Classification:

435408, 435363, 435366, 435375

Abstract:

The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.

US Patent:

8415158, Apr 9, 2013

Filed:

Feb 29, 2012

Appl. No.:

13/409059

Inventors:

Allan J Robins - Athens GA, US
Thomas C Schulz - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02

US Classification:

435383, 435405, 435325, 435404, 435384

Abstract:

The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.

US Patent:

8445273, May 21, 2013

Filed:

Aug 29, 2011

Appl. No.:

13/220590

Inventors:

Chad Green - San Diego CA, US
Xiaojie Yu - Irvine CA, US
Anne Bang - San Diego CA, US
Eugene Brandon - San Diego CA, US
Olivia Kelly - San Diego CA, US
Alan D Agulnick - San Diego CA, US
E Edward Baetge - Encinitas CA, US
Kevin A D'Amour - San Diego CA, US
Thomas C Schulz - Athens GA, US
Allan J Robins - Athens GA, US

Assignee:

ViaCyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/071
C12N 5/07
C12N 5/10

US Classification:

435363, 435377, 435383, 435384, 435366, 435375

Abstract:

The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.

US Patent:

8623650, Jan 7, 2014

Filed:

Oct 19, 2007

Appl. No.:

11/875057

Inventors:

Allan J. Robins - Athens GA, US
Thomas C. Schulz - Athens GA, US

Assignee:

Viacyte, Inc. - San Diego CA

International Classification:

C12N 5/00
C12N 5/02
C12N 5/10
C12N 5/071

US Classification:

435392, 435363, 435366, 435375

Abstract:

The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.