Allen R Howard

US Patent:

20020111294, Aug 15, 2002

Filed:

Oct 22, 2001

Appl. No.:

09/982940

Inventors:

Charles Grissom - Salt Lake City UT, US
Frederick West - Salt Lake City UT, US
Allen Howard - Dexter MI, US

International Classification:

A61K048/00
A61K051/00
A61K038/17
A61K009/00

US Classification:

514/006000, 514/044000, 424/043000

Abstract:

The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which comprise a bioactive agent and an organocobalt complex. The bioactive agent is covalently bonded directly or indirectly to the cobalt atom of the organocobalt complex. The bioactive agent is released from the bioconjugate by the cleavage of the covalent bond between the bioactive agent and the cobalt atom in the organocobalt complex. The cleavage may occur as a result of normal displacement by cellular nucleophiles or enzymatic action, but is preferably caused to occur selectively as a predetermined release site by application of an external signal. The external signal may be light or photoexcitation, i.e. photolysis, or it may be ultrasound, i.e. sonolysis. Further, if the photolysis takes place in the presence of a magnetic field surrounding the release site, the release of the bioactive agent into surrounding healthy tissue is minimized.

US Patent:

63159783, Nov 13, 2001

Filed:

Oct 22, 1999

Appl. No.:

9/202328

Inventors:

Charles B. Grissom - Salt Lake City UT
Frederick G. West - Salt Lake City UT
Allen W. Howard - Dexter MI

Assignee:

University of Utah, Research Foundation - Salt Lake City UT

International Classification:

A61K 5100
A61K 4900
A61K 39385
A61B 5055
A01N 6100

US Classification:

424 153

Abstract:

The present invention relates to bioconjugates and the delivery of bioactive agents which are preferably targeted for site-specific release in cells, tissues or organs. More particularly, this invention relates to bioconjugates which comprise of bioactive agent and an organocobalt complex. The bioactive agent is covalently bonded directly or indirectly to the cobalt atom of the organocobalt complex. The bioactive agent is released from the bioconjugate by the cleavage of the covalent bond between the bioactive agent and the cobalt atom in the organocobalt complex. The cleavage may occur as a result of normal displacement by cellular nucleophiles or enzymatic action, but is preferably caused to occur selectively at a predetermined release site by application of an external signal. The external signal may be light or photoexcitation, i. e. photolysis, or it may be ultrasound, i. e.