Allison J Chin

US Patent:

6518268, Feb 11, 2003

Filed:

Jun 30, 2000

Appl. No.:

09/608636

Inventors:

Allison C. Chin - Stanford CA
Ryan Holcomb - San Carlos CA
Mieczyslaw A. Piatyszek - Morgan Hill CA
Upinder Singh - Fremont CA
Richard L. Tolman - Los Altos CA
Tsutomu Akama - Redwood City CA
Yutaka Kanda - Tokyo, JP
Akira Asai - Sagamihara, JP
Yoshinori Yamashita - Tokyo, JP
Kaori Endo - Kamakura, JP
Hiroyuki Yamaguchi - Tokyo, JP

Assignee:

Geron Corporation - Menlo Park CA
Kyowa Hakko Kogyo Co., Ltd. - Tokyo

International Classification:

A61K 31535

US Classification:

5142368, 51425402, 514369, 514386, 544133, 544367, 548183

Abstract:

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

7998938, Aug 16, 2011

Filed:

Apr 14, 2006

Appl. No.:

11/918581

Inventors:

Malcolm A.S. Moore - New York NY, US
Allison C. Chin - Stanford CA, US

Assignee:

Geron Corporation - Menlo Park CA
Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

A16K 48/00

US Classification:

514 44, 536 245, 435325, 435375

Abstract:

A method and kit for inhibiting the proliferation of cancer cells are disclosed, based on a combination of a proteasome inhibitor and a telomerase inhibitor. When used in cancer therapy, the two compounds in combination enhance the anti-cancer treatment efficacy obtained with the proteasome inhibitor alone or the telomerase inhibitor alone. Preferably, efficacy is supraadditive or synergistic in nature relative to the combined effects of the individual agents, with minimal exacerbation of side effects.

US Patent:

20020115700, Aug 22, 2002

Filed:

Feb 13, 2002

Appl. No.:

10/077738

Inventors:

Allison Chin - Stanford CA, US
Richard Tolman - Los Altos CA, US
Mark Nguyen - San Jose CA, US
Ryan Holcomb - San Carlos CA, US

International Classification:

C07D417/02

US Classification:

514/369000, 548/183000

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

6372742, Apr 16, 2002

Filed:

Jun 30, 2000

Appl. No.:

09/608861

Inventors:

Allison C. Chin - Stanford CA
Richard L. Tolman - Los Altos CA
Mark Q. Nguyen - San Jose CA
Ryan Holcomb - San Carlos CA

Assignee:

Geron Corporation - Menlo Park CA

International Classification:

A61K 314166

US Classification:

5142368, 51425402, 514369, 544133, 544367, 548183

Abstract:

5-(3-Isatinylidinyl)thiazolidineones and 3-(thiazolidinon-5-yl)indoles compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

US Patent:

20210361558, Nov 25, 2021

Filed:

Aug 4, 2021

Appl. No.:

17/393929

Inventors:

- Paris, FR
Allison Chin - Hoboken NJ, US
Anthony Potin - East Rutherford NJ, US

International Classification:

A61K 8/92
A61Q 5/00
A61K 8/34
A61K 8/42
A61K 8/365
A61K 8/37
A61Q 5/06

Abstract:

The present disclosure relates to hair-treatment compositions, which are particularly useful for providing styling, hair manageability, hair care, and conditioning properties to hair. The hair-treatment compositions typically include: (a) about 1 to about 3 wt. % of one or more vegetable oils; (b) about 2 to about 4 wt. % of one or more solid fatty alcohols; (c) 1 wt. % or less of one or more nonionic surfactants; (d) one or more non-silicone shine enhancers; (e) one or more amidoamines: (f) one or more acids; and (g) water. The unique combination of ingredients results in a product having a milky appearance and a fluid viscosity. Kits comprising the hair-treatment compositions and methods of treating hair using the hair-treatment compositions are also disclosed.

US Patent:

20190029949, Jan 31, 2019

Filed:

Jul 31, 2017

Appl. No.:

15/665189

Inventors:

- Paris, FR
Allison Chin - Hoboken NJ, US
Anthony Potin - East Rutherford NJ, US

Assignee:

L'OREAL - Paris

International Classification:

A61K 8/92
A61Q 5/00
A61K 8/34
A61K 8/37
A61K 8/42
A61K 8/365

Abstract:

The present disclosure relates to hair-treatment compositions, which are particularly useful for providing styling, hair manageability, hair care, and conditioning properties to hair. The hair-treatment compositions typically include: (a) about 1 to about 3 wt. % of one or more vegetable oils; (b) about 2 to about 4 wt. % of one or more solid fatty alcohols; (c) 1 wt. % or less of one or more nonionic surfactants; (d) one or more non-silicone shine enhancers; (e) one or more amidoamines: (f) one or more acids; and (g) water. The unique combination of ingredients results in a product having a milky appearance and a fluid viscosity. Kits comprising the hair-treatment compositions and methods of treating hair using the hair-treatment compositions are also disclosed.

US Patent:

20180116937, May 3, 2018

Filed:

Oct 31, 2016

Appl. No.:

15/339029

Inventors:

- Paris, FR
Allison CHIN - Hoboken NJ, US
Kamini PATEL - Iselin NJ, US
Heather LEE - Wayne NJ, US
Jaimie MECCA - Clifton NJ, US
Ivana RASHID - New York NY, US

International Classification:

A61K 8/60
A61Q 5/02
A61Q 19/10
A61K 8/37
A61K 8/42
A61K 8/46
A61K 8/73

Abstract:

The present disclosure relates to cleansing compositions, which are free of sulfates and ethoxylated surfactants. Methods for making and using the cleansing compositions are also described. The cleansing compositions include: (a) at least 3 wt. % of one or more nonionic surfactant(s) that are not fatty esters; (b) one or more fatty ester(s); (c) one or more non-ethoxylated, sulfate-free anionic surfactant(s); and (d) two or more thickening agents. The cleansing compositions exhibit quality cleansing activity, impart pleasant conditioning benefits, and have a desired viscosity and foam properties.