Ami M Patel

US Patent:

20220370598, Nov 24, 2022

Filed:

May 5, 2022

Appl. No.:

17/662141

Inventors:

- Plymouth Meeting PA, US
- Philadelphia PA, US
David Weiner - Merion PA, US
Kar Muthumani - Cherry Hill NJ, US
Ami Patel - Philadelphia PA, US

International Classification:

A61K 39/215
A61P 31/14
A61K 9/00

Abstract:

Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-γ) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.

US Patent:

20220324948, Oct 13, 2022

Filed:

Jul 31, 2020

Appl. No.:

17/631709

Inventors:

- Philadelphia PA, US
Elizabeth Parzych - Philadelpha PA, US
Ami Patel - Philadelphia PA, US

International Classification:

C07K 16/12
A61P 31/00

Abstract:

Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including one or more recombinant nucleic acid sequence that encodes a synthetic antibody or synthetic multivalent antibody to the subject. The disclosure also provides a compositions and methods of preventing and/or treating a infection in a subject using said synthetic antibody or synthetic multivalent antibody.

US Patent:

20220275065, Sep 1, 2022

Filed:

Jul 31, 2020

Appl. No.:

17/631691

Inventors:

- Philadelphia PA, US
Ami Patel - Philadelphia PA, US

International Classification:

C07K 16/12
A61K 9/00
A61K 31/711

Abstract:

Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including a recombinant nucleic acid sequence that encodes an antibody, a synthetic antibody, or a synthetic multivalent antibody to a subject. The disclosure also provides compositions and methods of preventing and/or treating a bacterial infection in a subject using said antibody, synthetic antibody, or synthetic multivalent antibody.

US Patent:

20230063151, Mar 2, 2023

Filed:

Jan 29, 2021

Appl. No.:

17/759649

Inventors:

- Philadelphia PA, US
Ami Patel - Philadelphia PA, US
Megan C. Wise - Glenside PA, US
Sarah T.C. Elliott - Pullman WA, US

International Classification:

A61K 39/395
A61P 37/02
C07K 16/10
C07K 16/12
C07K 16/28

Abstract:

Disclosed herein are combinations of inhibitors of B cell maturation and recombinant nucleic acid molecules encoding synthethic antibodies, and their use for extending the duration of circulating synthetic antibodies and for treating diseases and disorders.

US Patent:

20210268102, Sep 2, 2021

Filed:

Feb 25, 2021

Appl. No.:

17/185458

Inventors:

- Plymouth Meeting PA, US
- Philadelphia PA, US
David Weiner - Merion PA, US
Kar Muthumani - Cherry Hill NJ, US
Ami Patel - Philadelphia PA, US

International Classification:

A61K 39/215
C12N 15/86

Abstract:

Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.

US Patent:

20200362055, Nov 19, 2020

Filed:

Jan 31, 2019

Appl. No.:

16/966513

Inventors:

- Philadelphia PA, US
Makan Khoshnejad - Philadelphia PA, US
Kar Muthumani - Cherry Hill NJ, US
Ami Patel - Philadelphia PA, US

International Classification:

C07K 16/40
A61P 3/06

Abstract:

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.

US Patent:

20200216519, Jul 9, 2020

Filed:

Sep 17, 2018

Appl. No.:

16/647082

Inventors:

- Philadelphia PA, US
Ami Patel - Philadelphia PA, US

International Classification:

C07K 16/10
A61P 31/14

Abstract:

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.

US Patent:

20190091322, Mar 28, 2019

Filed:

Mar 21, 2017

Appl. No.:

16/087146

Inventors:

David B. Weiner - Merion PA, US
Karuppiah Muthumani - Cherry Hill NJ, US
Seleeke Flingai - Minneapolis MN, US
Niranjan Sardesai - Blue Bell PA, US
Sarah Elliott - Pullman WA, US
Jian Yan - Wallingford PA, US
Ami Patel - Philadelphia PA, US

International Classification:

A61K 39/12
A61K 39/42
C07K 16/10

Abstract:

Disclosed herein is a composition comprising the combination of a nucleic acid sequence encoding a desired polypeptide that elicits an immune response in a mammal and a nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof.