Amie S Corbin

US Patent:

7416873, Aug 26, 2008

Filed:

Oct 17, 2007

Appl. No.:

11/873985

Inventors:

Brian J. Druker - Portland OR, US
Amie Corbin - Portland OR, US

Assignee:

Oregon Health & Science University - Portland OR

International Classification:

C12N 9/12
C07K 1/00

US Classification:

435194, 530350

Abstract:

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

7592142, Sep 22, 2009

Filed:

Jul 24, 2008

Appl. No.:

12/178926

Inventors:

Brian J. Druker - Portland OR, US
Amie Corbin - Portland OR, US

Assignee:

Oregon Health and Science University - Portland OR

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20030170851, Sep 11, 2003

Filed:

Oct 3, 2002

Appl. No.:

10/263480

Inventors:

Christophe Barthe - Merignac, FR
Pascale Cony-Makhoul - Annecy, FR
Amie Corbin - Portland OR, US
Sven De Vos - Santa Monica CA, US
Brian Druker - Portland OR, US
Harald Gschaidmeier - Nurnberg, DE
Michael Hallek - Schondorf, DE
Andreas Hochhaus - Mannheim German, DE
Dieter Hoelzer - Frankfurt/Main, DE
Wolf-Karsten Hofmann - Goldbach, DE
Phillip Koeffler - Los Angeles CA, US
Sebastian Kreil - Mannheim, DE
Francois-Xavier Mahon - Bordeaux, FR
Martin Muller - Heidelberg, DE
Oliver Ottmann - Frankfurt/Main, DE
Markus Warmuth - Starnberg, DE

International Classification:

G01N033/53
C07H021/04
C12N009/12
C12P021/02
C12N005/06

US Classification:

435/194000, 435/069100, 435/320100, 435/325000, 536/023200, 435/007100

Abstract:

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20050202519, Sep 15, 2005

Filed:

Oct 4, 2002

Appl. No.:

10/491603

Inventors:

Christophe Barthe - Martignas Sur Jalles, FR
Susan Branford - South Australia, AU
Amie Corbin - Portland OR, US
Brian Druker - Portland OR, US
Justus Duyster - Munich, DE
Andreas Hochhaus - Mannheim, DE
Timothy Hughes - South Australia, AU
Sebastian Kreil - Mannheim, DE
Thibaut Leguay - Bordeaux, FR
Francois-Xavier Mahon - Bordeaux, DE
Gerald Marit - Bordeaux, DE
Martin Muller - Heidelberg, DE
Chriatian Peschel - Munich, DE
Claude Preudhomme - Houdain, FR
Catherine Roche Lestienne - Lille, FR
Zbigniew Rudzki - South Australia, AU

International Classification:

C12Q001/48
C07H021/04
C12N009/12
C12N015/09

US Classification:

435015000, 435194000, 435069100, 435320100, 435325000, 536023200

Abstract:

The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20060148058, Jul 6, 2006

Filed:

Jan 31, 2006

Appl. No.:

11/343891

Inventors:

Christophe Barthe - Merignac, FR
Pascale Cony-Makhoul - Annecy, FR
Amie Corbin - Portland OR, US
Sven De Vos - Santa Monica CA, US
Brian Druker - Portland OR, US
Harald Gschaidmeier - Nurnberg, DE
Michael Hallek - Schondorf, DE
Andreas Hochhaus - Mannheim, DE
Dieter Hoelzer - Frankfurt/Main, DE
Wolf-Karsten Hofmann - Goldbach, DE
Phillip Koeffler - Los Angeles CA, US
Sebastian Kreil - Mannheim, DE
Francois-Xavier Mahon - Bordeaux, FR
Martin Muller - Heidelberg, DE
Oliver Ottmann - Frankfurt/Main, DE
Markus Warmuth - Starnberg, DE

International Classification:

C12N 9/12

US Classification:

435194000

Abstract:

The tides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit they tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20070077640, Apr 5, 2007

Filed:

Sep 20, 2006

Appl. No.:

11/524626

Inventors:

Brian Druker - Portland OR, US
Amie Corbin - Portland OR, US

International Classification:

C12N 9/12
C07H 21/04
C12P 21/06

US Classification:

435194000, 435069100, 435320100, 435325000, 536023200

Abstract:

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20090117641, May 7, 2009

Filed:

Jun 30, 2008

Appl. No.:

12/165217

Inventors:

Christophe Barthe - Martignas Sur Jalles, FR
Susan Bradford - Flagstaff Hill, AU
Amie Corbin - Portland OR, US
Brian Jay Druker - Portland OR, US
Justus Duyster - Munich, DE
Andreas Hochhaus - Mannheim, DE
Timothy Hughes - Kensington Gardens, AU
Sebastian Kreil - Mannheim, DE
Thibaut Leguay - Bordeaux, FR
Francios-Xavier Mahon - Bordeaux, FR
Gerald Marit - Bordeaux, FR
Martin Muller - Heidelberg, DE
Christian Peschel - Munich, DE
Claude Preudhomme - Houdain, FR
Catherine Roche Lestienne - Lille, FR
Zbigniew Rudzki - Rostrevor, AU

International Classification:

C12N 9/12

US Classification:

435194

Abstract:

The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

US Patent:

20090191606, Jul 30, 2009

Filed:

Dec 17, 2008

Appl. No.:

12/337322

Inventors:

Christophe Barthe - Merignac, FR
Pascale Cony-Makhoul - Annecy, FR
Amie Corbin - Portland OR, US
Sven De Vos - Santa Monica CA, US
Brian Jay Druker - Portland OR, US
Harald Gschaidmeier - Nurnberg, DE
Michael Hallek - Schondorf, DE
Andreas Hochhaus - Mannheim, DE
Dieter Hoelzer - Frankfurt/Main, DE
Wolf-Karsten Hofmann - Goldbach, DE
Phillip Koeffler - Los Angeles CA, US
Sebastian Kreil - Mannheim, DE
Francois-Xavier Mahon - Bordeaux, FR
Martin Muller - Heidelberg, DE
Oliver Gerhard Ottmann - Frankfurt/Main, DE
Markus Warmuth - Starnberg, DE

International Classification:

C12N 9/12
C07H 21/00
C12N 15/63
C12N 5/10

US Classification:

435194, 536 232, 4353201, 435325

Abstract:

The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1 -ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.