Amy T Anderson

US Patent:

7118676, Oct 10, 2006

Filed:

Sep 3, 2004

Appl. No.:

10/934597

Inventors:

Daniel Mueth - Chicago IL, US
Joseph Plewa - Park Ridge IL, US
Jessica Shireman - Kansas City MO, US
Amy Anderson - Prospect Heights IL, US
Lewis Gruber - Chicago IL, US
Neil Harris Rosenbaum - Chicago IL, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B01D 21/01

US Classification:

210732, 210800, 210802, 210927, 4351731, 422 72, 422 8205, 422101, 436177

Abstract:

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

US Patent:

7150834, Dec 19, 2006

Filed:

Jun 13, 2004

Appl. No.:

10/867328

Inventors:

Daniel M. Mueth - Chicago IL, US
Amy Anderson - Prospect Heights IL, US
Jessica Shireman - Kansas City MO, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B01D 21/01

US Classification:

210732, 210800, 210802, 210927, 4351731, 422 72, 422 8205, 422101, 436177

Abstract:

The invention provides a method and apparatus for separating blood into components, may be expanded to include other types of cellular components, and can be combined with holographic optical manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

US Patent:

7355696, Apr 8, 2008

Filed:

Feb 1, 2005

Appl. No.:

11/046896

Inventors:

Daniel Mueth - Chicago IL, US
Amy L. Anderson - Prospect Heights IL, US
Christopher R. Knutson - Chicago IL, US
Joseph Plewa - Park Ridge IL, US

Assignee:

Arryx, Inc - Chicago IL

International Classification:

G01N 21/01

US Classification:

356244, 356246, 356 39, 209 31

Abstract:

Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detect desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.

US Patent:

7402131, Jul 22, 2008

Filed:

Oct 6, 2006

Appl. No.:

11/543773

Inventors:

Daniel Mueth - Chicago IL, US
Joseph Plewa - Park Ridge IL, US
Jessica Shireman - Kansas City MO, US
Amy Anderson - Prospect Heights IL, US
Lewis Gruber - Chicago IL, US
Neil Harris Rosenbaum - Chicago IL, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B04B 7/08

US Classification:

494 36, 494 45

Abstract:

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

US Patent:

7545491, Jun 9, 2009

Filed:

Feb 14, 2008

Appl. No.:

12/071020

Inventors:

Daniel Mueth - Chicago IL, US
Amy Anderson - Palatine IL, US
Christopher Knutson - Chicago IL, US
Joseph Plewa - Park Ridge IL, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

G01N 21/47
G01N 21/01

US Classification:

356244, 356246, 356442

Abstract:

Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.

US Patent:

7699767, Apr 20, 2010

Filed:

Jun 13, 2008

Appl. No.:

12/213109

Inventors:

Daniel Mueth - Chigago IL, US
Joseph Plewa - Park Ridge IL, US
Jessica Shireman - Kansas City MO, US
Amy Anderson - Prospect Heights IL, US
Lewis Gruber - Chicago IL, US
Neil Harris Rosenbaum - Chicago IL, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B04B 7/08

US Classification:

494 36, 494 45

Abstract:

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

US Patent:

7704395, Apr 27, 2010

Filed:

Nov 8, 2006

Appl. No.:

11/594094

Inventors:

Daniel Mueth - Chicago IL, US
Amy Anderson - Prospect Heights IL, US
Jessica Shireman - Kansas City MO, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B01D 36/02
B01D 21/00

US Classification:

2103231, 210348, 422 8205, 422 8206, 422 8211, 422101, 422104, 250251

Abstract:

The invention provides a method and apparatus for separating blood into components, may be expanded to include other types of cellular components, and can be combined with holographic optical manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

US Patent:

8158927, Apr 17, 2012

Filed:

Mar 2, 2010

Appl. No.:

12/659277

Inventors:

Daniel Mueth - Chicago IL, US
Joseph Plewa - Park Ridge IL, US
Jessica Shireman - Kansas City MO, US
Amy Anderson - Palatine IL, US
Lewis Gruber - Chicago IL, US
Neil Harris Rosenbaum - Chicago IL, US

Assignee:

Arryx, Inc. - Chicago IL

International Classification:

B01D 21/01

US Classification:

250251, 494 36, 494 45, 4351731, 210732, 210800, 210802

Abstract:

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.