Amy Xin Chen

US Patent:

7231638, Jun 12, 2007

Filed:

Dec 3, 2002

Appl. No.:

10/308734

Inventors:

Robert S. Blackmore - Poughkeepsie NY, US
Amy Xin Chen - Poughkeepsie NY, US
Rama K. Govindaraju - Hopewell Junction NY, US
Chulho Kim - Poughkeepsie NY, US
Hanhong Xue - Wappingers Falls NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 15/167
G06F 12/00
G06F 12/06

US Classification:

718108, 709212, 709216, 711 2

Abstract:

A method is provided for sharing and/or transporting data within a single node of a multi-node data processing. The method avoids the necessity of making more than one copy of the data to be shared or transported. The method is tunable based on the size of the data segment involved. A shared memory area between tasks running in different address spaces on the node is used to coordinate the process and for task to task communication. The increase in efficiency provided by the intranodal process described herein also provides advantages to the internodal communication process since more CPU cycles are available for that aspect of system operation.

US Patent:

7379444, May 27, 2008

Filed:

Jan 27, 2003

Appl. No.:

10/351823

Inventors:

Robert S. Blackmore - Poughkeepsie NY, US
Amy X. Chen - Poughkeepsie NY, US
Scott D. Epter - Rhinebeck NY, US
Chulho Kim - Poughkeepsie NY, US
Rajeev Sivaram - Poughkeepsie NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H04L 1/12
H04L 12/26

US Classification:

370342, 370216

Abstract:

Epoch numbers are maintained in a pair wise fashion at a plurality of communication endpoints to provide communication consistency and recovery from a range of failure conditions including total or partial node failure and subsequent recovery. Once an epoch state inconsistency is recognized, negotiation procedures provide an effective mechanism to reestablish valid communication links without the need to employ global variables which inherently possess greater transmission and overhead requirements needed to maintain communications. Renegotiation of recognizably valid epoch numbers occurs on a pair wise basis.

US Patent:

8116210, Feb 14, 2012

Filed:

May 23, 2008

Appl. No.:

12/126371

Inventors:

Robert S. Blackmore - Poughkeepsie NY, US
Amy X. Chen - Poughkeepsie NY, US
Scott D. Epter - Rhinebeck NY, US
Chulho Kim - Poughkeepsie NY, US
Rajeev Sivaram - Poughkeepsie NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G01R 31/08
G06F 11/00

US Classification:

370242, 370216, 370252, 714 18, 714 25

Abstract:

Epoch numbers are maintained in a pair wise fashion at a plurality of communication endpoints to provide communication consistency and recovery from a range of failure conditions including total or partial node failure and subsequent recovery. Once an epoch state inconsistency is recognized, negotiation procedures provide an effective mechanism to reestablish valid communication links without the need to employ global variables which inherently possess greater transmission and overhead requirements needed to maintain communications. Renegotiation of recognizably valid epoch numbers occurs on a pair wise basis.

US Patent:

20030014516, Jan 16, 2003

Filed:

Jul 13, 2001

Appl. No.:

09/905308

Inventors:

Robert Blackmore - Poughkeepsie NY, US
Amy Chen - Poughkeepsie NY, US
Kevin Gildea - Bloomington NY, US
Rama Govindaraju - Poughkeepsie NY, US
Anand Hudli - Hopewell Junction NY, US
Radha Kandadai - Lake Katrine NY, US
Chulho Kim - Poughkeepsie NY, US
Richard Rosenthal - Poughkeepsie NY, US
Gautam Shah - Poughkeepsie NY, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - ARMONK NY

International Classification:

G06F015/173

US Classification:

709/224000, 709/238000

Abstract:

Interconnected data processing nodes can from time to time experience temporary failures or losses of communication links between system nodes. In systems which have a mechanism for determining whether the data processing nodes are operative or not, by providing an epoch number for use as an instance identifier and by providing a mechanism for controlling the generation and propagation of the epoch number, such systems are able to resume their respective tasks when failed nodes or communication links are restored.

US Patent:

20030023775, Jan 30, 2003

Filed:

Jul 13, 2001

Appl. No.:

09/904815

Inventors:

Robert Blackmore - Poughkeepsie NY, US
Amy Chen - Poughkeepsie NY, US
Kevin Gildea - Bloomington NY, US
Rama Govindaraju - Poughkeepsie NY, US
Anand Hudli - Hopewell Junction NY, US
Radha Kandadai - Lake Katrine NY, US
Chulho Kim - Poughkeepsie NY, US
Gautam Shah - Poughkeepsie NY, US

Assignee:

INTERNATIONAL BUSINESS MACHINES CORPORATION - ARMONK NY

International Classification:

G06F009/00
G06F009/46

US Classification:

709/330000, 709/313000, 709/318000, 709/328000

Abstract:

A system and method for message processing in a distributed, multi-node data processing system is structured to permit a sending process running on one node to send messages to a selectable subset of nodes via an interface mechanism which places a sending process in an inactive or idle state pending receipt of either all responses from the selected destination nodes or of a notification via the interface that one or more responses will not arrive.

US Patent:

20030225874, Dec 4, 2003

Filed:

May 30, 2002

Appl. No.:

10/159163

Inventors:

Robert Blackmore - Poughkeepsie NY, US
Amy Chen - Poughkeepsie NY, US
Rama Govindaraju - Hopewell Junction NY, US
Chulho Kim - Poughkeepsie NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F015/173

US Classification:

709/223000

Abstract:

The sending of acknowledgments is managed. An acknowledgment is delayed by a receiver until a threshold number of packets is received by the receiver or another condition is satisfied, unless a further condition arises that provokes the sending of the acknowledgment prematurely. This allows delaying techniques to be used in situations in which such techniques are typically not tolerated.

US Patent:

20220196651, Jun 23, 2022

Filed:

Dec 6, 2021

Appl. No.:

17/543569

Inventors:

- South San Francisco CA, US
Bang Janet SIM - South San Francisco CA, US
Amy Shaw-Ru CHEN - San Jose CA, US
Emma Ruth SANGALANG - Oakland CA, US

International Classification:

G01N 33/543
G01N 33/80
G01N 33/566
C07K 14/705
C07K 16/28

Abstract:

Provided are methods of reducing and/or preventing interference by a drug comprising (i) an antibody Fc region and (ii) a moiety that binds to human CD47 in serological assays.

US Patent:

20210054087, Feb 25, 2021

Filed:

Aug 27, 2020

Appl. No.:

17/005073

Inventors:

- NEW YORK NY, US
Javier Fernando CHAPARRO RIGGERS - San Mateo CA, US
Wei CHEN - Cupertino CA, US
Amy Shaw-Ru CHEN - San Jose CA, US
Edward Derrick PASCUA - Oakland CA, US
Thomas John VAN BLARCOM - Oakland CA, US
Leila Marie BOUSTANY - Redwood City CA, US
Weihsien HO - Belmont CA, US
Yik Andy YEUNG - South San Francisco CA, US
Pavel STROP - San Mateo CA, US
Arvind RAJPAL - San Francisco CA, US

Assignee:

PFIZER INC. - NEW YORK NY

International Classification:

C07K 16/28
A61K 39/395
A61K 31/454
A61K 31/704
A61K 31/69
A61K 47/68

Abstract:

The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.