Shomir Ghosh - Brookline MA, US Amy M. Elder - Arlington MA, US Kenneth G. Carson - Needham MA, US Kevin Sprott - Boston MA, US Sean Harrison - Belmont MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 215/38 C07D 215/44
US Classification:
546157, 546159, 514313, 514314
Abstract:
Disclosed herein are compounds represented by Structural Formula (I):Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2 (“CRTH2”) for the treatment of inflammatory disorders.
Chemokine Receptor Antagonists And Methods Of Use Thereof
Jay R. Luly - Wellesley MA, US Yoshisuke Nakasato - Shizuoka, JP Etsuo Ohshima - Nagareyama, JP Geraldine C. B. Harriman - Charlestown RI, US Kenneth G. Carson - Needham MA, US Shomir Ghosh - Brookline MA, US Amy M. Elder - Arlington MA, US Karen M. Mattia - Marlborough MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA Kyowa Hakko Kogyo Co., Ltd. - Tokyo
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: formula (1) or physiologically acceptable salt thereof.
Pgd2 Receptor Antagonists For The Treatment Of Inflammatory Diseases
Shomir Ghosh - Brookline MA, US Amy M. Elder - Arlington MA, US Kenneth G. Carson - Princeton NJ, US Kevin T. Sprott - Boston MA, US Sean J. Harrison - Belmont MA, US Frederick A. Hicks - Somerville MA, US Christelle C. Renou - Somerville MA, US Dominic Reynolds - Cambridge MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 215/38
US Classification:
546112, 546152, 546159
Abstract:
Disclosed herein are compounds represented by Structural Formula (I) and (I-A):Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply “CRTH2” for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
Chemokine Receptor Antagonists And Methods Of Use Therefor
Jay R. Luly - Wellesley MA, US Yoshisuke Nakasato - Shizuoka, JP Etsuo Ohshima - Nagareyama, JP Geraldine C. B. Harriman - Charlestown RI, US Kenneth G. Carson - Needham MA, US Shomir Ghosh - Brookline MA, US Amy M. Elder - Arlington MA, US Karen M. Mattia - Marlborough MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA Kyowa Hakko Kogyo Co., Ltd. - Tokyo
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by:.
Pgd2 Receptor Antagonists For The Treatment Of Inflammatory Diseases
Jeremy D. Little - Wakefield MA, US Shomir Ghosh - Brookline MA, US Sean Harrison - Belmont MA, US Amy M. Elder - Arlington MA, US Christelle C. Renou - Somerville MA, US Kenneth G. Carson - Princeton NJ, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 215/38
US Classification:
546159
Abstract:
Disclosed are CRTH2 inhibitors represented by Structural Formula (I):.
Indu T. Bharathan - Cambridge MA, US Matthew Duffey - Boston MA, US Amy Elder - Arlington MA, US Jianping Guo - Winchester MA, US Gang Li - Westborough MA, US Dominic Reynolds - Stoneham MA, US Francois Soucy - Stoneham MA, US Tricia J. Vos - Medford MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D 487/04 A61K 31/55
US Classification:
51421206, 540521
Abstract:
This invention provides compounds of formula I:.
Chemokine Receptor Antagonists And Methods Of Use Therefor
Jay R. Luly - Wellesley MA, US Yoshisuke Nakasato - Shizuoka, JP Etsuo Ohshima - Nagareyama, JP Geraldine C. B. Harriman - Charlestown RI, US Kenneth G. Carson - Needham MA, US Shomir Ghosh - Brookline MA, US Amy M. Elder - Arlington MA, US Karen M. Mattia - Marlborough MA, US
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA Kyowa Hakko Kirin Co., Ltd. - Tokyo
Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by:.
Amy M. Elder - Arlington MA, US Shomir Ghosh - Brookline MA, US Sian Griffiths - Westborough MA, US Prakash Raman - Acton MA, US Francois Soucy - Stoneham MA, US Kevin Sprott - Boston MA, US Qing Ye - Westborough MA, US
The present invention provides compounds of general formula (I) or a pharmaceutically acceptable salt thereof, wherein X, n, Y, and Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR2 and accordingly are useful for the treatment of a variety of inflammatory, allergic, and autoimmune diseases, disorders, or conditions.
Gene Ward Elementary School Las Vegas NV 1983-1986, Hyde Park Junior High School Las Vegas NV 1991-1993, Greenspun Middle School Las Vegas NV 1992-1994