Amy L Gentry

US Patent:

20020094989, Jul 18, 2002

Filed:

Oct 10, 2001

Appl. No.:

09/974000

Inventors:

Jeffrey Hale - Westfield NJ, US
Christopher Lynch - Scotch Plains NJ, US
Charles Caldwell - Scotch Plains NJ, US
Christopher Willoughby - Greenbrook NJ, US
Dooseop Kim - Westfield NJ, US
Sander Mills - Scotch Plains NJ, US
Kevin Chapman - Scotch Plains NJ, US
Liya Chen - East Brunswick NJ, US
Amy Gentry - New York NY, US
Malcolm MacCoss - Freehold NJ, US
Zenon Konteatis - Chatham NJ, US

International Classification:

A61K031/496
A61K031/4745
A61K031/4439
C07D471/02
C 07D 4 3/02
C 07D 4 1/02

US Classification:

514/253040, 514/254010, 514/254060, 514/303000, 514/322000, 514/326000, 544/362000, 544/368000, 544/372000, 546/113000, 546/119000, 546/208000

Abstract:

Pyrrolidine compounds of Formula I: (wherein , R, R, R, R,R, R, Rand Rare defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful, for example, in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.