Amy Sim Lee

US Patent:

7049132, May 23, 2006

Filed:

Jun 28, 2000

Appl. No.:

09/606804

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00
C12N 15/09
C12N 15/63
C12N 15/70
C12N 15/74

US Classification:

4353201, 514 44, 424 932

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

7378427, May 27, 2008

Filed:

Jun 17, 2005

Appl. No.:

11/155851

Inventors:

Brian Hugh Ridgway - Belmont CA, US
William Jay Moore - Collegeville PA, US
Mark Anthony Ashwell - Carlisle MA, US
William Ronald Solvibile - East Windsor NJ, US
Amy Tsai-Ting Lee - Los Altos CA, US
Molly Elizabeth Hoke - Hightstown NJ, US
Madelene Antane - West Windsor NJ, US
Amedeo A. Failli - Princeton Junction NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/44
C07D 221/12

US Classification:

514298, 546108

Abstract:

Synthetic methods are provided for production of compounds of the formula:.

US Patent:

7666220, Feb 23, 2010

Filed:

Jul 7, 2006

Appl. No.:

11/482503

Inventors:

Michael A. Evans - Palo Alto CA, US
Gwendolyn A. Watanabe - Sunnyvale CA, US
Amy Lee - Sunnyvale CA, US
Steven L. Herbowy - Palo Alto CA, US

Assignee:

Nellix, Inc. - Palo Alto CA

International Classification:

A61F 2/06

US Classification:

623 125, 623 132

Abstract:

Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon.

US Patent:

7923243, Apr 12, 2011

Filed:

Aug 27, 2004

Appl. No.:

10/928806

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00

US Classification:

4353201

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

8048145, Nov 1, 2011

Filed:

Apr 28, 2006

Appl. No.:

11/413460

Inventors:

Michael A. Evans - Palo Alto CA, US
Gwendolyn A. Watanabe - Sunnyvale CA, US
Amy Lee - Sunnyvale CA, US
Steven L. Herbowy - San Francisco CA, US

Assignee:

Endologix, Inc. - Irvine CA

International Classification:

A61F 2/06

US Classification:

623 125, 606194, 606195, 623 132

Abstract:

Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

US Patent:

8392538, Mar 5, 2013

Filed:

Aug 1, 2012

Appl. No.:

13/564609

Inventors:

Amy Lee - San Mateo CA, US

Assignee:

Luminate, Inc. - Mountain View CA

International Classification:

G06F 15/16

US Classification:

709219, 709203, 709217

Abstract:

Disclosed herein are systems and methods for displaying images and contextually relevant content on a digital content platform, such as a web page. In one embodiment, for example, the systems and methods include: (1) providing a publisher of the image with a reference script for publication with the image, wherein the reference script is a computer-readable instruction that causes an end-user device to call to a content server; and (2) configuring the content server to (a) receive a request for content from the end-user device, (b) identify content that is contextually relevant to the image, (c) deliver the content to the end-user device, and (d) deliver a computer-readable instruction that causes the end-user device to perform an animation that modifies the image and displays the content in a spatial relationship with respect to the image as originally published.

US Patent:

8445455, May 21, 2013

Filed:

Apr 12, 2011

Appl. No.:

13/084772

Inventors:

Amy Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/70

US Classification:

514 44R

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

20050143291, Jun 30, 2005

Filed:

Oct 26, 2004

Appl. No.:

10/975045

Inventors:

Amy Lee - San Marino CA, US

International Classification:

A61K048/00
A61K038/16

US Classification:

514008000, 514044000

Abstract:

This invention relates to compositions and methods for modulating apoptosis by regulating the activity of endoplasmic reticulum transmembrane glucose regulated protein 78 (GRP78).