Amy H Lin

US Patent:

20130266931, Oct 10, 2013

Filed:

Jul 16, 2011

Appl. No.:

13/810403

Inventors:

Douglas J. Jolly - Encinitas CA, US
Omar Perez - San Diego CA, US
Amy Lin - San Diego CA, US

Assignee:

TOCAGEN INC. - San Diego CA

International Classification:

C12Q 1/70

US Classification:

435 5, 536 2432

Abstract:

Provided are methods and compositions useful for detecting viral infection or contamination in a biological sample.

US Patent:

20130323301, Dec 5, 2013

Filed:

Oct 31, 2011

Appl. No.:

13/882487

Inventors:

Harry E. Gruber - Rancho Santa Fe CA, US
Douglas J. Jolly - Encinitas CA, US
Derek G. Ostertag - San Diego CA, US
Ryan S. Burnett - San Diego CA, US
Amy H. Lin - San Diego CA, US
Tiffany Huang - San Diego CA, US
Joan M. Robbins - San Diego CA, US

Assignee:

TOCAGEN INC. - San Diego CA

International Classification:

A61K 31/7088
A61K 31/573
A61N 5/10
A61K 9/127
A61K 31/713
A61K 39/395
A61K 31/58

US Classification:

424450, 514169, 424 932, 514 44 R, 4241741, 4241581, 514179, 514180, 514174, 514 44 A, 600 1

Abstract:

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

US Patent:

20220195460, Jun 23, 2022

Filed:

Dec 16, 2021

Appl. No.:

17/553697

Inventors:

- San Diego CA, US
Douglas J. JOLLY - Encinitas CA, US
Amy H. LIN - San Diego CA, US
Joan M, ROBBINS - San Diego CA, US
Derek G. OSTERTAG - San Diego CA, US

Assignee:

DENOVO BIOPHARMA LLC - San Diego CA

International Classification:

C12N 15/86
A61K 38/20
A61K 38/21
C12N 15/113
A61K 35/76
A61K 31/7088
A61K 48/00

Abstract:

The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.

US Patent:

20210361691, Nov 25, 2021

Filed:

Mar 1, 2021

Appl. No.:

17/189169

Inventors:

- San Diego CA, US
Douglas J. Jolly - Encinitas CA, US
Derek G. Ostertag - San Diego CA, US
Ryan S. Burnett - San Diego CA, US
Amy H. Lin - San Diego CA, US
Tiffany Huang - San Diego CA, US
Joan M. Robbins - San Diego CA, US

Assignee:

DENOVO BIOPHARMA, LLC - San Diego CA

International Classification:

A61K 31/7088
A61K 39/21
C12N 15/867
A61K 31/56
A61K 39/395
A61K 35/768
A61K 9/127
A61K 31/573
A61K 31/58
A61K 31/713
A61N 5/10

Abstract:

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

US Patent:

20180251786, Sep 6, 2018

Filed:

Sep 1, 2016

Appl. No.:

15/757292

Inventors:

- San Diego CA, US
Amy H. Lin - San Diego CA, US
Andrew Hofacre - Laguna Niguel CA, US
Daniel J. Hogan - San Diego CA, US
Derek G. Ostertag - San Diego CA, US

International Classification:

C12N 15/86
A61P 35/00
C07K 14/535
C07K 14/705

Abstract:

This disclosure provides modified recombinant retroviruses comprisings containing a 2A-peptide or peptide-like coding sequence operably linked to a heterologous polynucleotide. The disclosure further relates to cells and vector expressing or comprising such vectors and methods of using such modified vectors in the treatment of disease and disorders.

US Patent:

20180021365, Jan 25, 2018

Filed:

Jun 1, 2017

Appl. No.:

15/611722

Inventors:

- San Diego CA, US
Douglas J. Jolly - Encinitas CA, US
Derek G. Ostertag - San Diego CA, US
Ryan S. Burnett - San Diego CA, US
Amy H. Lin - San Diego CA, US
Tiffany Huang - San Diego CA, US
Joan M. Robbins - San Diego CA, US

International Classification:

A61K 31/7088
C12N 15/867
A61N 5/10
A61K 39/395
A61K 31/573
A61K 39/21
A61K 35/768
A61K 31/713
A61K 31/58
A61K 9/127
A61K 31/56

Abstract:

This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics.

US Patent:

20170175137, Jun 22, 2017

Filed:

Mar 25, 2015

Appl. No.:

15/127388

Inventors:

- San Diego CA, US
Douglas J. Jolly - Encinitas CA, US
Amy H. Lin - San Diego CA, US
Joan M. Robbins - San Diego CA, US
Derek G. Ostertag - San Diego CA, US

International Classification:

C12N 15/86
A61K 31/7088
A61K 38/21
A61K 38/20
A61K 48/00
C12N 15/113

Abstract:

The disclosure provides vectors for treating cancers, method of producing such vectors and methods of use of the vectors.

US Patent:

20160175388, Jun 23, 2016

Filed:

Jun 15, 2014

Appl. No.:

14/897847

Inventors:

- San Diego CA, US
Douglas J. Jolly - Encinitas CA, US
Amy H. Lin - San Diego CA, US

International Classification:

A61K 38/16
A61K 39/395
C07K 14/005

Abstract:

The disclosure provides for one or more immunosuppressive components associated with retroviral replicating vectors (RRVs) that contribute to RRV tumor specificity and efficacy.