Amy Elizabeth Morgan

US Patent:

20030162164, Aug 28, 2003

Filed:

Apr 19, 2002

Appl. No.:

10/126345

Inventors:

Barry Bochner - Alameda CA, US
Amy Morgan - Oakland CA, US

Assignee:

BIOLOG, INC.

International Classification:

C12Q001/00
C12M001/34

US Classification:

435/004000, 435/287100

Abstract:

The present invention relates to growing and testing any cell type in a multitest format. The present invention is suited for the characterization of microorganisms, as well as animal and plant cells. The present invention is also particularly suited for analysis of phenotypic differences between strains of organisms, including cultures that have been designated as the same genus and species. The present invention is also suited for the analysis of phenotypic differences between cell lines. In some embodiments, a gel forming matrix is used. The present invention provides methods and compositions for the phenotypic analysis and comparison of eukaryotic, as well as prokaryotic cells. The present invention further provides novel methods and compositions for testing the effect(s) of biologically active chemicals on various cells.

US Patent:

20050260558, Nov 24, 2005

Filed:

Jul 27, 2005

Appl. No.:

11/192161

Inventors:

Barry Bochner - Alameda CA, US
Amy Morgan - Oakland CA, US

Assignee:

Biolog Inc. - Hayward CA

International Classification:

C12Q001/00
C12Q001/68

US Classification:

435004000

Abstract:

The present invention relates to growing and testing any cell type in a multitest format. The present invention is suited for the characterization of microorganisms, as well as animal and plant cells. The present invention is also particularly suited for analysis of phenotypic differences between strains of organisms, including cultures that have been designated as the same genus and species. The present invention is also suited for the analysis of phenotypic differences between cell lines. In some embodiments, a gel forming matrix is used. The present invention provides methods and compositions for the phenotypic analysis and comparison of eukaryotic, as well as prokaryotic cells. The present invention further provides novel methods and compositions for testing the effect(s) of biologically active chemicals on various cells.

US Patent:

57863369, Jul 28, 1998

Filed:

Sep 19, 1994

Appl. No.:

8/305993

Inventors:

Lawrence M. Kauvar - San Francisco CA
Matthew H. Lyttle - Point Reyes Station CA
Amy S. Morgan - Oakland CA
Richard F. Borch - Pittsford NY

Assignee:

Terrapin Technologies, Inc. - South San Francisco CA

International Classification:

A61K 3806
C07K 508

US Classification:

514 18

Abstract:

A method to potentiate the effect of a chemotherapeutic agent in a tumor cell, which method comprises administering to said tumor cell, along with said chemotherapeutic agent, a potentiating amount of a compound of the formula: ##STR1## or an amide, ester or hybrid amide/ester thereof, wherein X is a hydrocarbon radical optionally substituted on any aromatic moiety contained therein; Y--CO is. gamma. -Glu or. beta. -Asp and AA. sub. C is an amino acid, preferably glycine, phenylglycine,. beta. -alanine, alanine or phenylalanine is disclosed. Similar compounds can also be used to selectively exert cytotoxicity versus target cells as compared to nontarget cells and also to elevate the production of GM progenitors in bone marrow of mammalian subjects.

US Patent:

57670862, Jun 16, 1998

Filed:

Jun 7, 1995

Appl. No.:

8/482645

Inventors:

Lawrence M. Kauvar - San Francisco CA
Matthew H. Lyttle - Point Reyes Station CA
Amy S. Morgan - Oakland CA
Richard F. Borch - Pittsford NY

Assignee:

Terrapin Technologies, Inc. - South San Francisco CA

International Classification:

A61K 3806
C07K 508

US Classification:

514 18

Abstract:

Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is. gamma. -glu or. beta. -asp; G* is phenyl glycine or glycine; Z is CH. sub. 2, O or S; and X is a hydrocarbon radical of 1-20 C; are useful in stimulating the differentiation of bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.

US Patent:

59554320, Sep 21, 1999

Filed:

Jul 3, 1996

Appl. No.:

8/675095

Inventors:

Lawrence M. Kauvar - San Francisco CA
Amy S. Morgan - Oakland CA
Matthew H. Lyttle - Point Reyes Station CA
Richard F. Borch - Pittsford NY

Assignee:

Terrapin Technologies, Inc. - S. San Francisco CA

International Classification:

A61K 3806
C07K 508

US Classification:

514 18

Abstract:

Compounds of the formula ##STR1## and the esters, amides, amide/esters and salts thereof, wherein YCO is. gamma. -glu or. beta. -asp; G* is phenylglycine or glycine; Z is CH. sub. 2, O or S; and X is a hydrocarbon radical selected from C. sub. 6 -C. sub. 8 alkyl or selected aromatic groups are useful in modulating hematopoiesis in bone marrow, mitigating the bone-marrow-destructive effects of a chemotherapeutic agent, and in potentiating the toxicity of chemotherapeutic agents.