Amy L Palmer

US Patent:

20120241643, Sep 27, 2012

Filed:

Jan 28, 2012

Appl. No.:

13/360706

Inventors:

Amy E. Palmer - Boulder CO, US
Ralph Jimenez - Boulder CO, US
Kevin Dean - Lafayette CO, US
Jennifer Lubbeck - Boulder CO, US
Lloyd M. Davis - Tullahoma TN, US

International Classification:

G01N 21/64

US Classification:

250428

Abstract:

Devices and methods for screening emissive properties of a cell, such as the resistance to photobleaching or other photophysical property. In one example, a device may include a microfluidic reservoir having at least an input channel for receiving the cell, a main channel fluidly coupled with the input channel, at least a first output channel and a second output channel, the first and second output channels fluidly coupled with the main channel; and a multibeam interrogation section generating a plurality of light beams impinging upon the main channel of the microfluidic reservoir. As a cell passes from the input channel through the main channel of the microfluidic reservoir, the cell is exposed to the plurality of light beams thereby generating emissions that are received by a signal processing section. A cell trapping section selectively diverts the cell to the second output channel if the cell contains desired emissive properties.