Amy B Thompson

US Patent:

7473548, Jan 6, 2009

Filed:

Apr 25, 2003

Appl. No.:

10/423112

Inventors:

Orhan Soykan - Shoreview MN, US
Maura G. Donovan - St. Paul MN, US
Amy E. Thompson - Coon Rapids MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

C12M 1/34

US Classification:

4352871

Abstract:

Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy at the second and third wavelengths.

US Patent:

8594809, Nov 26, 2013

Filed:

Mar 30, 2009

Appl. No.:

12/414384

Inventors:

Zhongping Yang - Woodbury MN, US
Amy Elizabeth Thompson - Coon Rapids MN, US
Paulus G. Adams - Munstergeleen, NL
Koen Michels - Maastricht, NL

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61N 1/18

US Classification:

607126

Abstract:

An implantable passive fixation lead is disclosed. The passive fixation lead comprises an elongate lead body having at least one elongate conductive element. The lead body includes a proximal end and a distal end. A support member has a first surface and a second surface. The second surface is coupled to the distal end of the lead body. A linking material is coupled to the first surface of the support member. A bioadhesive material is coupled to the linking material. A removable cover is placed over the bioadhesive material.

US Patent:

20120046642, Feb 23, 2012

Filed:

Aug 22, 2011

Appl. No.:

13/214860

Inventors:

Orhan Soykan - Shoreview MN, US
Maura G. Donovan - St. Paul MN, US
Amy E. Thompson - Coon Rapids MN, US

Assignee:

Medtronic, Inc. - Minneapolis MN

International Classification:

A61M 5/168

US Classification:

604503, 604 66

Abstract:

Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first wavelength into the bodily fluid, and detects energy at second and third wavelengths emitted by the dyes in response to the energy at the first wavelength. Prior to enzymatic cleavage of the substrate, the acceptor emits energy at the third wavelength in response to energy at the second wavelength received through fluorescent resonant energy transfer (FRET) from the donor. After enzymatic cleavage of the substrate, the donor emits energy at the second wavelength. The device can determine the concentration of activated enzyme within the bodily fluid based on the relative intensities of energy at the second and third wavelengths.