Anand Vijay Kumar

US Patent:

51457873, Sep 8, 1992

Filed:

Dec 5, 1991

Appl. No.:

7/803134

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Miles, Inc. - Tarrytown NY

International Classification:

G01N 2178
G01N 3320

US Classification:

436 79

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic crypt and compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and --Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 to 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

50454757, Sep 3, 1991

Filed:

Jun 1, 1988

Appl. No.:

7/201576

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

G01N 2178

US Classification:

436 74

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and --Q-- is ##STR2## wherein X and CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

50735012, Dec 17, 1991

Filed:

Jan 30, 1989

Appl. No.:

7/304356

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

G01N 3320

US Classification:

436 74

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen. lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and -Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

49943952, Feb 19, 1991

Filed:

Apr 15, 1987

Appl. No.:

7/038741

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

G01N 3320
G01N 3120
G01N 3350
C07D49802

US Classification:

436 79

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising (a) one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and --Q-- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## and (b) one or more interfering cation complexing compound masks.

US Patent:

58145214, Sep 29, 1998

Filed:

Aug 28, 1996

Appl. No.:

8/703982

Inventors:

Eddy Chapoteau - Brooklyn NY
Jonathan Craine - Monsey NY
Bronislaw P. Czech - Peekskill NY
Anand Kumar - Pleasanton CA
Koon-wah Leong - Sunnyvale CA

Assignee:

Bayer Corporation - Tarrytown NY

International Classification:

G01N 3320
G01N 35546

US Classification:

436 74

Abstract:

The present invention relates to a method for the determination of polyvalent metal ions using a sandwich aggregation assay. One or more chelating agents capable of forming at least 2:1 or higher ratio stoichiometry complexes with polyvalent metal ions are attached to a suitable carrier such as latex particles through covalent bonds or by non-covalent interactions, such as hydophobic interactions. Upon complexation with the metal ions, the carriers of the complexing agent aggregate, causing an increase in light absorbance or light scattering which is proportional to the concentration of metal ions in the test sample. The measurement of the light absorbance or light scattering by a suitable instrument, such as a spectrophotometer or nephelometer provides a means for measuring the concentration of metal ions.

US Patent:

48085391, Feb 28, 1989

Filed:

Apr 15, 1987

Appl. No.:

7/038843

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Technicon Instruments Corporation - Tarrytown NY

International Classification:

G01N 3320

US Classification:

436 74

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent comprising one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and -Q- is ##STR2## wherein X is CH, N, or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is selected from the group consisting of p-nitrophenylazo, 3-phenylisothiazalyl -5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino and bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.

US Patent:

50968319, Mar 17, 1992

Filed:

May 13, 1991

Appl. No.:

7/699188

Inventors:

Eddy Chapoteau - Brooklyn NY
Bronislaw P. Czech - Peekskill NY
Carl R. Gebauer - Crompond NY
Koon-Wah Leong - Ossining NY
Anand Kumar - Southfields NY

Assignee:

Miles Inc. - Tarrytown NY

International Classification:

G01N 2178
G01N 3320

US Classification:

436 74

Abstract:

The invention is reagents and procedures for determining an amount of cations present in a sample, the reagent including one or more chromogenic cryptand compounds of formula I ##STR1## wherein k and j, either same or different, are equal to 1 to about 5; m and n, either same or different, are equal to 0 to about 4; a and e, either same or different, are equal to 0 to about 2; b and d, either same or different, are equal to 0 to about 5; R, either same or different, is hydrogen, lower alkyl, lower alkylidene, lower alkenyl, allyl, or aryl; and ##STR2## wherein X is CH, N or COH; and Y includes ##STR3## except that when Q is ##STR4## wherein Y is p-nitrophenylazo, 3-phenylisothiazolyl-5-azo, isothiazolyl-5-azo, thiazolyl-5-azo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino or bis-(p-dimethylaminophenyl)hydroxymethyl, then the following condition cannot be present: that simultaneously b is equal to 0 or 1, d is equal to 0 or 1, j is equal to 1, n is equal to 1 or 2, a is equal to 1, e is equal to 1, k is equal to 1 and m is equal to 2.