Richard Malley - Beverly MA, US Porter Anderson - Key Largo FL, US Yingjie Lu - West Roxbury MA, US George A. Robertson - Fairfax Station VA, US Mark Alderson - Bainbridge Island WA, US Jean-Francois Lucien Maisonneuve - Federal Way WA, US Andrea Maria Tate - Issaquah WA, US Waldely de Oliveira Dias - Sao Paulo, BR Viviane Maimoni Gonçalves - Sao Paulo, BR
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA FUNDACAO BUTANTAN - Sao Paulo PATH VACCINE SOLUTIONS - Seattle WA
International Classification:
A61K 39/02 A61P 37/04 A61P 31/04 A61K 39/09
US Classification:
4242441, 4242341
Abstract:
The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cell by selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.