Andreas Rohrwasser - Salt Lake City UT Terry Morgan - Salt Lake City UT Jean-Marc Lalouel - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 137
US Classification:
435 23, 436 86, 514 2, 530316, 424 9466
Abstract:
The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
Drug Screening And Diagnosis Based On Paracrine Tubular Renin-Angiotensin System
Andreas Rohrwasser - Salt Lake City UT, US Terry Morgan - Salt Lake City UT, US Jean-Marc Lalouel - Salt Lake City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C07K 7/14 C12Q 1/37
US Classification:
435 23, 436 86, 514 2, 530316, 530860
Abstract:
The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.
Molecular Variants, Haplotypes And Linkage Disequilibrium Within The Human Angiotensinogen Gene
Jean-Marc Lalouel - Salt Lake City UT, US Andreas Rohrwasser - Salt Lake City UT, US Tomoaki Ishigami - Yokohama, JP Mitsuru Emi - Tokyo, JP Toshiaki Nakajima - Kawasaki, JP Ituro Inoue - Tokyo, JP
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
The present invention relates to methods for assessing risk of hypertension in als by identifying the molecular variants or haplotypes of the angiotensinogen (AGT) gene.
Method To Determine Predisposition To Hypertension
Andreas Rohrwasser - Salt Lake City UT Jean-Marc Lalouel - Salt Lake City UT
Assignee:
University of Utah Research Foundation - Salt Lake City UT
International Classification:
C12Q 168 C07H 2104
US Classification:
435 6
Abstract:
The T/C(67) AGT gene variant and the association of the molecular variant C(67) with predisposition of an individual to hypertension are disclosed. The determination of this association enables the screening of persons to identify the severity of hypertension or the severity of the risk of a predisposition to high blood pressure.