Andres N Garcia

US Patent:

8114431, Feb 14, 2012

Filed:

Sep 19, 2007

Appl. No.:

11/857819

Inventors:

Andres J. Garcia - Atlanta GA, US
Catherine D. Reyes - Miami FL, US
Timothy Petrie - Atlanta GA, US
Zvi Schwartz - Atlanta GA, US
Barbara D. Boyan - Atlanta GA, US
Jenny E. Raynor - E. Sandwich MA, US
David M. Collard - Atlanta GA, US
Abigail M. Wojtowicz - Atlanta GA, US
Robert E. Guldberg - Marietta GA, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

A61F 2/00
A61K 38/00
A61K 51/00
C07K 2/00
C07K 4/00
C07K 5/00
C07K 7/00
C07K 9/00
C07K 16/00
C07K 17/00

US Classification:

424423, 530300, 424 169, 514 11

Abstract:

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an αβor αβintegrin-specific ligand are provided. The substrates and devices coated with an αβor αβintegrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

US Patent:

20060237390, Oct 26, 2006

Filed:

Apr 14, 2006

Appl. No.:

11/279808

Inventors:

William King - Smyrna GA, US
Andres Garcia - Atlanta GA, US
Joseph Charest - Atlanta GA, US
Nathan Gallant - Atlanta GA, US

International Classification:

B44C 1/22
C23F 1/00

US Classification:

216041000, 216052000

Abstract:

The invention is a method for fabricating a cell culture surface substrate, comprising the steps of a) forming a cell culture surface having a mechanical topography, b) forming a synthetic chemical pattern using a chemical pattern template, and c) combining the cell culture surface having a mechanical topography and the synthetic chemical pattern. Mechanical topography is defined as a pattern of mechanical structures with regular and specifically designed features. The synthetic chemical pattern is defined as a group of features of specific chemistry different from the chemistry of their surroundings that have regular and specifically designed features.

US Patent:

20110008404, Jan 13, 2011

Filed:

Dec 19, 2008

Appl. No.:

12/809433

Inventors:

Louis Andrew Lyon - Marietta GA, US
Andres J. Garcia - Atlanta GA, US
Julia E. Babensee - Atlanta GA, US

Assignee:

Georgia Tech Research Corporation - Atlanta GA

International Classification:

A61K 9/00
A61K 47/30
A61P 29/00
A61P 17/02
H05H 1/00

US Classification:

424422, 5147726, 427569

Abstract:

The various embodiments of the present disclosure relate generally to the modification of biomaterials with microgel films. More particularly, the various embodiments of the present invention are directed to the modification of biomaterials and medical devices with microgel thin films to alter a host's response to an implanted biomaterial or medical device. An embodiment of the present invention comprises a coated biomaterial comprising a non-fouling polymer film attached to at least a portion of a surface of the biomaterial, the non-fouling polymer film comprising a plurality of a cross-linked polymer microparticles, wherein at least a portion of the cross-linked polymer microparticles are covalently bonded to at least a portion of the surface of the biomaterial.

US Patent:

20120142597, Jun 7, 2012

Filed:

Feb 13, 2012

Appl. No.:

13/372234

Inventors:

Andres J. Garcia - Atlanta GA, US
Catherine D. Reyes - Miami FL, US
Timothy Petrie - Atlanta GA, US
Zvi Schwartz - Atlanta GA, US
Barbara D. Boyan - Atlanta GA, US
Jenny E. Raynor - E. Sandwich MA, US
David M. Collard - Atlanta GA, US
Abigail M. Wojtowicz - Atlanta GA, US
Robert E. Guldberg - Marietta GA, US

International Classification:

A61K 38/16
A61P 19/08
A61K 38/39
C07K 14/00
C07K 14/78

US Classification:

514 167, 530324, 530350

Abstract:

Methods and compositions are provided for improving tissue growth and device integration in vivo. Substrates and devices coated with an αβor αβintegrin-specific ligand are provided. The substrates and devices coated with an αβor αβintegrin-specific ligand are shown to have greater tissue formation on the surface relative to controls, in particular greater bone formation.

US Patent:

20210236686, Aug 5, 2021

Filed:

Jul 23, 2019

Appl. No.:

17/263021

Inventors:

- Atlanta GA, US
Andres J. GARCIA - Atlanta GA, US
Young C. JANG - Atlanta GA, US

International Classification:

A61L 26/00
A61M 37/00
A61J 1/20

Abstract:

Disclosed herein are hydrogels that can be loaded with myogenic agents, for instance muscle stem cells (MuSCs)/satellite cells, pro-myogenic factors, and combinations thereof. The hydrogels can be contacted with damaged muscle tissue, thereby facilitating muscle growth and repair. Further provided are methods of repairing muscle tissue in a patient in need thereof, said methods comprising contacting the muscle tissue with a composition comprising the hydrogel. Also provided herein are kits comprising the hydrogel composition and a substrate comprising at least one microneedle.

US Patent:

20200176089, Jun 4, 2020

Filed:

Dec 3, 2018

Appl. No.:

16/207579

Inventors:

- Atlanta GA, US
Andres Garcia - Atlanta GA, US

International Classification:

G16H 10/20
G16H 15/00
G06Q 10/06
G16H 70/40

Abstract:

Systems, methods, and computer-readable media are disclosed for generating automated actions using artificial intelligence and composite audit trail events. Example devices may include at least one processor configured to determine a first score for completion of a plurality of tasks digitally completed by users associated with a clinical trial site identifier, determine an average document cycle time, generate, based at least in part on the first score and the average document cycle time, an estimated startup time value, and determine a second score for compliance with digital tasks. In some instances, the at least one processor may be configured to generate a digital user interface comprising a first graphical indicator representing the first score, a second graphical indicator representing the average document cycle time, a third graphical indicator representing the estimated startup time value, and a fourth graphical indicator representing the second score, and present the digital user interface.

US Patent:

20200118693, Apr 16, 2020

Filed:

Oct 25, 2019

Appl. No.:

16/663762

Inventors:

- Atlanta GA, US
Andres Garcia - Atlanta GA, US

International Classification:

G16H 80/00
G06F 21/10
G16H 10/20

Abstract:

Systems, methods, and computer-readable media are disclosed for remote monitoring and dynamic document management. Example methods may include receiving a first document from a device driver associated with a hardware device, identifying a clinical trial identifier associated with the first document based at least in part on metadata associated with the first document, and determining a first document type of the first document by analyzing contents of the first document. Methods may include managing user permission to access the first document. Methods may further include identifying a folder associated with the clinical trial identifier at which to store the first document based at least in part on the first document type, and assigning a first document state to the first document based at least in part on the first document type of the first document.

US Patent:

20190040363, Feb 7, 2019

Filed:

Oct 1, 2018

Appl. No.:

16/148784

Inventors:

- Atlanta GA, US
Shalu Suri - Ithaca NY, US
Todd Christopher McDevitt - Atlanta GA, US
Hang Lu - Atlanta GA, US
Andres Jose Garcia - Atlanta GA, US

International Classification:

C12N 5/074
G01N 33/569
C12Q 1/686
C12N 5/0797

Abstract:

The present invention provides for methods of isolating a stem cell or cell derived therefrom from a mixture of cells, for example, a mixture of adherent cells in culture. Cell isolation is achieved by the application of selective detachment forces.