Andrew M Beck

US Patent:

20220375606, Nov 24, 2022

Filed:

May 18, 2022

Appl. No.:

17/747536

Inventors:

- Boston MA, US
Surya Teja CHAVALI - Boston MA, US
Syed Ashar JAVED - Boston MA, US
Shamira Sridharan WEAVER - Boston MA, US
Murray RESNICK - Boston MA, US
Ilan WAPINSKI - Brookline MA, US
Michael MONTALTO - Boston MA, US
Andrew Hanno BECK - Brookline MA, US
Aditya KHOSLA - Watertown MA, US

International Classification:

G16H 50/20
G16H 70/60
G06V 10/25
G06T 7/00

Abstract:

Techniques for performing diagnostic assessments based on digital pathology data are disclosed. In one particular embodiment, the techniques may be realized as a method for performing a diagnostic assessment based on digital pathology data comprising obtaining first digital pathology data comprising intensity information, the first digital pathology data being associated with a plurality of regions of interest in a biological sample; applying first machine learning models to the first digital pathology data, the first machine learning models identifying first regions of interest among the plurality of regions of interest based on the intensity information; applying second machine learning models to the first digital pathology data, the second machine learning models identifying at least one pattern associated with at least one of the first regions of interest; generating a diagnostic assessment based on the first regions of interest and the at least one pattern.

US Patent:

20230099074, Mar 30, 2023

Filed:

Oct 26, 2022

Appl. No.:

18/049711

Inventors:

- Rahway NJ, US
- La Jolla CA, US
Jeffrey Kern - Gilbertsville PA, US
Linda Liang - Mountain View CA, US
Sanjiv Shah - Wakefield MA, US
Dennis Zaller - Boston MA, US
Andrew Beck - San Diego CA, US
Dennis Gately - San Diego CA, US
Nick Knudsen - Escondido CA, US
Anthony Manibusan - San Diego CA, US
Jianing Wang - San Diego CA, US
Ying Sun - San Diego CA, US

Assignee:

Merck Sharp & Dohme LLC - Rahway NJ
Ambrx, Inc. - La Jolla CA

International Classification:

A61K 47/68
C07K 16/28

Abstract:

Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.

US Patent:

20200164085, May 28, 2020

Filed:

Sep 30, 2016

Appl. No.:

15/765515

Inventors:

- Rahway NJ, US
- La Jolla CA, US
Jeffrey Kern - Gilbertsville PA, US
Linda Liang - Mountain View CA, US
Sanjiv Shah - Wakefield MA, US
Dennis Zaller - Boston MA, US
Andrew Beck - San Diego CA, US
Dennis Gately - San Diego CA, US
Nick Knudsen - Escondido CA, US
Anthony Manibusan - San Diego CA, US
Jianing Wang - San Diego CA, US
Ying Sun - San Diego CA, US

International Classification:

A61K 47/68
C07K 16/28

Abstract:

Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.

US Patent:

20170182181, Jun 29, 2017

Filed:

Mar 30, 2015

Appl. No.:

15/301564

Inventors:

- Rahway NJ, US
- La Jolla CA, US
Philip E. Brandish - Needham MA, US
Sanjiv Shah - Wakefield MA, US
Linda Liang - Mountain View CA, US
Ying Sun - San Diego CA, US
Jianing Wang - San Diego CA, US
Nick Knudsen - Escondido CA, US
Andrew Beck - San Diego CA, US
Anthony Manibusan - San Diego CA, US
Dennis Gately - San Diego CA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Ambrx, Inc. - La Jolla CA

International Classification:

A61K 47/48
C07K 16/28
C07J 41/00
C07J 43/00

Abstract:

Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).