Andrew L Darling

US Patent:

20080020049, Jan 24, 2008

Filed:

Aug 21, 2007

Appl. No.:

11/842796

Inventors:

Andrew Darling - Bradford VT, US
Lauren Shor - Devon PA, US
Wei Sun - Cherry Hill NJ, US
Selcuk Guceri - Moorestown NJ, US

International Classification:

A61K 35/12
A61K 9/14
C12M 3/00

US Classification:

424489000, 424093700, 435289100, 435325000

Abstract:

In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective layer and optionally (c) a filler. In another aspect, the invention includes a method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material having a porosity of between 15-90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns.

US Patent:

20110165646, Jul 7, 2011

Filed:

Sep 8, 2010

Appl. No.:

12/877818

Inventors:

Andrew Darling - Bradford VT, US
Lauren Shor - Devon PA, US
Wei Sun - Cherry Hill NJ, US

International Classification:

C12N 11/00
B29C 47/00
B29C 47/06
B29C 47/88

US Classification:

435174, 264178 R, 2641711

Abstract:

In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective layer and optionally (c) a filler. In another aspect, the invention includes a method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material having a porosity of between 15-90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns.

US Patent:

20160046078, Feb 18, 2016

Filed:

Oct 28, 2015

Appl. No.:

14/924801

Inventors:

- Philadelphia PA, US
Jae Hyun Nam - Broomall PA, US
Andrew Leete Darling - Syracuse NY, US
Saif Khalil - King of Prussia PA, US

International Classification:

B29C 67/00
C12N 5/071
G05B 19/4099

Abstract:

One aspect of the invention provides a method for multi-nozzle biopolymer deposition of heterogeneous materials to create or modify a composite biopolymer multi-part three-dimensional assembly having at least one biomimetic and at least one non-biomimetic feature. The method includes: (a) utilizing a CAD environment to design and/or modify a composite multi-part assembly, thereby producing a CAD design; (b) converting the CAD design into a three-dimensional heterogeneous material and multi-part assembly model in a format suitable for three-dimensional, multi-nozzle printing, wherein the design comprises at least one biomimetic feature and at least one non-biomimetic feature; and (c) printing the composite assembly by simultaneously depositing the heterogeneous materials using multiple, different, specialized nozzles, wherein the simultaneous depositing includes direct deposition of cells.

US Patent:

20140129019, May 8, 2014

Filed:

Jan 13, 2014

Appl. No.:

14/153764

Inventors:

- Philadelphia PA, US
Jae Hyun Nam - Broomall PA, US
Andrew Leete Darling - Syracuse NY, US
Saif Khalil - King of Prussia PA, US

Assignee:

DREXEL UNIVERSITY - Philadelphia PA

International Classification:

G05B 19/042
A61K 47/36

US Classification:

700 98, 700119

Abstract:

One aspect of the invention provides a material delivery system including: a plurality of nozzles and one or more controllers adapted and configured to control the plurality of nozzles to simultaneously deposit heterogeneous materials including one or more cells to manufacture a part or device. Another aspect of the invention provides a method including simultaneously depositing heterogeneous materials including one more cells using a plurality of nozzles.