Andrew T Hudson

US Patent:

20070254917, Nov 1, 2007

Filed:

Jan 12, 2007

Appl. No.:

11/622997

Inventors:

Robert Higuchi - Solana Beach CA, US
Steven Roach - San Diego CA, US
Lin Zhi - San Diego CA, US
Mark Adams - San Diego CA, US
Yan Liu - San Diego CA, US
Donald Karanewsky - Escondido CA, US
Andrew Hudson - San Diego CA, US

International Classification:

C07D 215/00
A61K 31/47
A61P 1/00
A61P 11/00
A61P 17/00
A61P 25/00
G01N 33/569
C07D 215/20
A61P 3/00
A61P 35/00
A61P 37/00
A61P 9/00

US Classification:

514312000, 435007210, 514311000, 544333000, 546152000, 546153000

Abstract:

This invention relates to compounds that bind to intracellular receptors and/or modulate activity of intracellular receptors, and to methods for making and using such compounds.

US Patent:

20110003851, Jan 6, 2011

Filed:

May 6, 2010

Appl. No.:

12/775331

Inventors:

Lin Zhi - San Diego CA, US
Andrew R. Hudson - San Diego CA, US
Cornelis A. Van Oeveren - San Diego CA, US
Steven L. Roach - San Diego CA, US
Jason C. Pickens - San Diego CA, US
Yixing Shen - Encinitas CA, US
Catalina Cuervo - San Diego CA, US
Lino J. Valdez - San Diego CA, US
Jillian Basinger - San Diego CA, US
Virgina H. Grant - Vista CA, US

Assignee:

Ligand Pharmaceuticals, Inc. - San Diego CA

International Classification:

A61K 31/4709
C12Q 1/02
C12N 5/071
A61K 31/4439
A61K 31/427
A61K 31/40
C07D 401/04
C07D 417/04
C07D 209/42
A61P 9/00
A61P 31/00
A61P 25/00
A61P 37/00

US Classification:

514313, 435 29, 435375, 514341, 514371, 514419, 546162, 5462761, 548195, 548492

Abstract:

The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

US Patent:

20120295904, Nov 22, 2012

Filed:

Oct 12, 2010

Appl. No.:

13/501622

Inventors:

Lin Zhi - San Diego CA, US
Andrew R. Hudson - San Diego CA, US
Cornelis A. Van Oeveren - San Diego CA, US
Steven L. Roach - San Diego CA, US
Bijan Pedram - San Diego CA, US
Yixing Shen - Encinitas CA, US
Lino J. Valdez - San Diego CA, US
Jillian Basinger - San Diego CA, US
Virginia Heather Sharron Grant - San Diego CA, US
Jason C. Pickens - Chula Vista CA, US

Assignee:

LIGAND PHARMACEUTICALS INC. - La Jolla CA

International Classification:

C07D 401/12
C07D 471/04
A61K 31/4545
A61K 31/454
C07D 403/12
C12Q 1/02
C07D 413/14
A61K 31/5377
A61P 7/00
C12N 5/078
G01N 21/76
A61K 31/506
A61K 31/496

US Classification:

5142345, 544335, 514256, 546194, 514318, 546208, 514326, 544372, 51425401, 544141, 5142355, 544143, 544122, 544120, 435375, 435 613, 435 725

Abstract:

The present embodiments relate to compounds with physiological effects, such as the activation of hematopoietic growth factor receptors. The present embodiments also relate to use of the compounds to treat a variety of conditions, diseases and ailments such as hematopoietic conditions and disorders.

US Patent:

20130338139, Dec 19, 2013

Filed:

Jun 18, 2013

Appl. No.:

13/920974

Inventors:

- Grand Cayman, KY
Bryan Branstetter - Carlsbad CA, US
James Breitenbucher - Escondido CA, US
Brian Dyck - San Diego CA, US
Tawfik Gharbaoui - Escondido CA, US
Laurent Gomez - San Diego CA, US
Andrew Richard Hudson - San Diego CA, US
Tami Jo Marrone - Carlsbad CA, US
Troy Vickers - San Diego CA, US
Michael I. Weinhouse - Escondido CA, US

International Classification:

C07D 495/14
C07D 491/147
C07D 491/107
C07D 495/22
C07D 471/14
C07D 487/14
C07D 498/08
C07D 491/22

US Classification:

51421021, 514267, 544251, 51421115, 540544, 5142332, 544115, 51425216, 5142305, 544105, 544230, 514249, 514257, 544247, 540578, 514215, 514250, 51425202, 544238, 5142285, 544 586, 540575, 514218

Abstract:

Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.

US Patent:

20210340127, Nov 4, 2021

Filed:

Feb 26, 2019

Appl. No.:

16/976363

Inventors:

- Dallas TX, US
Brett C. Bookser - San Diego CA, US
Scott Burley - Oceanside CA, US
Andrew Hudson - San Diego CA, US
Marco Peters - Fallbrook CA, US
Benjamin Pratt - Encinitas CA, US
Aaron Thompson - San Diego CA, US
Joe Tran - San Marcos CA, US
Lino Valdez - San Diego CA, US

International Classification:

C07D 405/12
A61P 25/28
C07D 309/14
C07C 211/40
C07C 237/24
C07C 255/46
C07D 213/38
C07D 401/12
C07D 211/96
C07D 211/58
C07D 207/14
C07D 211/76
C07D 207/273

Abstract:

Substituted cyclohexyl chemical entities of Formula (I): wherein R, G, and Rhave any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

US Patent:

20210046045, Feb 18, 2021

Filed:

Jul 10, 2020

Appl. No.:

16/925926

Inventors:

- San Diego CA, US
Keith Marschke - San Diego CA, US
Virginia H. Grant - San Diego CA, US
Steven L. Roach - San Diego CA, US
Yixing Shen - Encinitas CA, US
Jason C. Pickens - San Diego CA, US
Bijan Pedram - San Diego CA, US
Cornelis Arjan van Oeveren - San Diego CA, US
Lino J. Valdez - San Diego CA, US
Andrew R. Hudson - San Diego CA, US

International Classification:

A61K 31/404
C07D 403/12
C07D 231/46
C07D 209/34
C07D 405/06
A61K 31/41
A61K 31/4152
A61K 31/4155
A61K 31/454
A61K 45/06
A61N 5/10
C07D 401/12
C12Q 1/18
C12Q 1/66
C07D 231/52

Abstract:

Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments include use of compounds to treat certain disorders, such as hematopoietic or neurological disorders.

US Patent:

20200181104, Jun 11, 2020

Filed:

Feb 14, 2020

Appl. No.:

16/791935

Inventors:

- San Diego CA, US
Andrew R. Hudson - San Diego CA, US
Mi Chen - San Diego CA, US
Johnny Y. Nagasawa - San Diego CA, US
Iriny Botrous - San Diego CA, US

International Classification:

C07D 305/14
C07C 237/24
C07D 309/14
C07D 295/135
C07D 257/04
C07D 211/62
C07D 205/04
C07D 307/22
C07D 241/04
C07D 263/32
C07D 267/10
C07D 498/08
C07D 493/08
C07D 311/96
C07D 401/04
C07D 239/42
C07D 241/12
C07D 213/64
C07D 491/10
C07C 311/14

Abstract:

Described herein are compounds that are semicarbazide-sensitive amine oxidase (SSAO) inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in treating or preventing a liver disease or condition.

US Patent:

20190046535, Feb 14, 2019

Filed:

Oct 18, 2018

Appl. No.:

16/164726

Inventors:

- Grand Cayman, KY
James Breitenbucher - Escondido CA, US
Brian Dyck - San Diego CA, US
Laurent Gomez - San Diego CA, US
Andrew Richard Hudson - San Diego CA, US
Tami Jo Marrone - Carlsbad CA, US
Marco Peters - San Diego CA, US
Troy Vickers - San Diego CA, US
Michael I. Weinhouse - Escondido CA, US

International Classification:

A61K 31/519
C07D 495/14
C07D 519/00
C07D 495/22
C07D 491/147
C07D 491/107
C07D 491/22
C07D 498/08
C07D 471/14
C07D 495/12
C07D 487/14
A61K 31/5377
A61K 31/541
A61K 31/5386
A61K 31/553
A61K 31/551
A61K 31/55

Abstract:

Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.