Andrew B Kelson

US Patent:

7129215, Oct 31, 2006

Filed:

Jan 4, 2006

Appl. No.:

11/325846

Inventors:

Natalia Aurrecoechea - Oakland CA, US
Andrew B. Kelson - San Carlos CA, US
Robert W. Macsata - Pleasanton CA, US
Louise Robinson - San Carlos CA, US
Anthony J. Sanchez - Oakland CA, US
Nicholas M. Santiago - San Francisco CA, US
Steven R. Schow - Redwood City CA, US
Reyna J. Simon - Los Gatos CA, US

Assignee:

Telik, Inc. - Palo Alto CA

International Classification:

A61K 38/05
A61K 38/06
C07K 5/02

US Classification:

514 18, 530330, 530331

Abstract:

Tripeptide and tetrapeptide thioethers, pharmaceutical compositions containing them, their pharmaceutical use, and their preparation. The compounds are useful in potentiating the cytotoxic effects of chemotherapeutic agents in tumor cells, selectively exerting toxicity in tumor cells, elevating the production of GM progenitors in bone marrow, stimulating the differentiation of bone marrow, mitigating the myelosuppressive effects of chemotherapeutic agents, and modulating hematopoiesis in bone marrow.

US Patent:

7872134, Jan 18, 2011

Filed:

Dec 12, 2007

Appl. No.:

11/955177

Inventors:

Edgardo Laborde - Foster City CA, US
Andrew B. Kelson - San Carlos CA, US
Wenli Ma - Union City CA, US
Kevin T. Weber - Carmel IN, US

Assignee:

Telik, Inc. - Palo Alto CA

International Classification:

C07F 9/572
C07F 9/576
C07F 9/24
A61K 31/664
A61K 31/675

US Classification:

546 22, 548413, 558169, 514 89, 514 91, 514118

Abstract:

2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.

US Patent:

57212651, Feb 24, 1998

Filed:

Jun 2, 1995

Appl. No.:

8/458178

Inventors:

Michael Tracy - Palo Alto CA
Andrew B. Kelson - San Carlos CA
Paul Workman - Wilmslow, GB2
Alexander D. Lewis - Bearsden, GB6
Eric O. Aboagye - Bearsden, GB6

Assignee:

SRI International - Menlo Park CA

International Classification:

C07D23302
C07D23304
C07D23354
C07D23328
C07D23368
A61K 31415

US Classification:

514396

Abstract:

Agents useful for detecting hypoxic tumor cells are provided. The compounds have the structural formula (I) ##STR1## Methods of using the compounds to detect hypoxic tumor cells are also provided, as are pharmaceutical compositions formulated with the novel compounds.