Andrew Knox

US Patent:

7893056, Feb 22, 2011

Filed:

Nov 6, 2008

Appl. No.:

12/265983

Inventors:

Donghui Qin - Collegeville PA, US
Beth Norton - Research Triangle Park NC, US
Andrew Nicholas Knox - Collegeville PA, US
Siegfried B. Christensen - Collegeville PA, US
Kelly M. Aubart - Collegeville PA, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

C07D 498/04
A61K 31/5383

US Classification:

5142305, 544105

Abstract:

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives, compositions containing them, the use of such compounds in the inhibition of bacterial peptide deformylase (PDF) activity, and in the treatment of bacterial infections. Specifically, the invention is directed to compounds of formula (I):.

US Patent:

20130045962, Feb 21, 2013

Filed:

Nov 6, 2008

Appl. No.:

12/741641

Inventors:

Donghui Qin - Collegeville PA, US
Beth Norton - Triangle Park NC, US
Xiangmin Liao - Collegeville PA, US
Andrew Nicholson Knox - Collegeville PA, US
Jinhwa Lee - Giheung-gu, KR
Yuhong Fang - Collegeville PA, US
Jason Christopher Dreabit - Collegeville PA, US
Andrew B. Benowitz - Collegeville PA, US
Kelly M. Aubart - Collegeville PA, US

International Classification:

C07D 403/04
C07D 239/49
A61K 31/505
C07D 487/08
C07D 413/04
A61K 31/5377
C07D 417/04
C07D 498/04
A61K 31/5383
A61K 31/55
C07D 491/056
C07D 491/048
C07D 401/12
C07D 487/04
C07D 471/04
C07D 401/04
C07D 413/12
C07D 401/14
C07D 413/14
C07D 405/12
C07D 491/08
C07D 409/12
C07D 417/12
C07D 239/48
C07D 417/14
A61K 31/519
A61P 31/04
A61K 31/506

US Classification:

5142102, 544328, 514256, 544317, 514274, 544295, 51425214, 544329, 514249, 544122, 5142358, 544327, 544105, 5142305, 540524, 51421208, 544230, 540521, 51421402, 51425215, 544254, 5142611

Abstract:

The present invention is directed to certain {2-(alkyl)-3-[2-(5-fluoro-4-pyrimidinyl)hydrazino]-3-oxopropyl}hydroxyformamide derivatives. Specifically, the invention is directed to compounds of formula (I):wherein R1, R2 and R3 are defined below and to pharmaceutically acceptable salts thereof. The compounds of this invention are bacterial peptide deformylase inhibitors and can be useful in the treatment of bacterial infections.

US Patent:

20130345120, Dec 26, 2013

Filed:

Mar 9, 2012

Appl. No.:

14/004105

Inventors:

Kelly M. Aubart - Collegeville PA, US
Andrew B. Benowitz - Collegeville PA, US
Yuhong Fang - Eagleville PA, US
James Hoffman - Ardmore PA, US
Joseph M. Karpinski - Stowe PA, US
Andrew Nicholson Knox - Philadelphia PA, US
Xiangmin Liao - Collegeville PA, US
Donghui Qin - Collegeville PA, US
Dongchuan Shi - Collegeville PA, US
Jared T. Spletstoser - Collegeville PA, US

Assignee:

Glaxosmithkline LLC - Philadelphia PA

International Classification:

C07K 5/078
C07D 401/12
C07D 231/06
C07D 403/12

US Classification:

514 26, 5462754, 514 2191, 514 24, 514 27, 546143, 548195, 548246, 5483561, 544238, 548143, 544131, 546162, 546122, 544329, 548261, 544336, 544317, 544408, 544277, 544324, 514275, 514341, 5483794, 514403, 5142365

Abstract:

The present invention relates to a compound of Formula (I):ora pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.