Andrew W Krause

US Patent:

55878326, Dec 24, 1996

Filed:

Oct 20, 1993

Appl. No.:

8/138067

Inventors:

Andrew W. Krause - Sparks MD

Assignee:

Biophysica Technologies, Inc. - Sparks MD

International Classification:

G02B 2106

US Classification:

359385

Abstract:

The confocal imaging system and method involve the imaging of a specimen under observation by projecting a light pattern of illumination spots simultaneously on the specimen. This is accomplished by a pattern array unit which transforms light from a light source into a desired pattern of illumination spots. Light detected from the specimen is confined to a pattern conforming to the pattern of the illumination spots by a detector masking unit which rejects light beyond the pattern. Image signals are created from the received light and stored, and the stored image signals are combined to form a complete image frame.

US Patent:

47952563, Jan 3, 1989

Filed:

Mar 9, 1987

Appl. No.:

7/023567

Inventors:

Andrew W. Krause - Baltimore MD
Charles G. Marianik - Plainsboro NJ
Ronald J. Kovach - Langhorne PA

Assignee:

Photon Technology International, Inc. - Princeton NJ

International Classification:

G01J 308
G01J 3427
G01N 2164

US Classification:

356320

Abstract:

A dual wavelength spectrophotometer produces a relatively small, high power, high duty cycle light spot from a single relatively low power multi-chromatic light source. A Xenon arc lamp light source is focused by an ellipsoidal mirror onto a rotating partially reflective optical chopper. The chopper comprises a wheel having mirrored segments alternately separated by transparent segments. Light reflected by the mirrored segments passes through a first monochromator which produces a first monochromatic light beam. Light transmitted through the transparent segments passes through a second monochromator and emerges as a second monochromatic light beam having a wavelength different from the wavelength of said first monochromatic light beam. The first and second monochromatic light beams are recombined into a single dual wavelength light beam that is reflected through a sample to be analyzed. Reflective front surfaces are employed throughout the system in order to minimize power loss.

US Patent:

59234660, Jul 13, 1999

Filed:

Dec 20, 1996

Appl. No.:

8/770423

Inventors:

Andrew W. Krause - Sparks MD
Minhua Liang - Woodbury MN
Robert L. Stehr - Gaithersburg MD

Assignee:

Biophysica Technologies, Inc. - Baltimore MD

International Classification:

G02B 2106

US Classification:

359389

Abstract:

The confocal imaging system and method involve the imaging of a specimen under observation by projecting a light pattern of illumination spots simultaneously on the specimen. This is accomplished by a pattern array unit which transforms light from a light source into a desired pattern of illumination spots, and reflects or rejects light outside the pattern. Light detected from the specimen is confined to a pattern conforming to the pattern of the illumination spots by the same pattern array unit which rejects light beyond the pattern, and rejected light from the pattern array unit is transmitted back to the light source. Image signals are created from the received light and stored, and the stored image signals are combined to form a complete image frame.